Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Trends Immunol. 2024 Mar;45(3):158-166. doi: 10.1016/j.it.2024.01.004. Epub 2024 Feb 21.
Mammalian stem cells govern development, tissue homeostasis, and regeneration. Following years of study, their functions have been delineated with increasing precision. The past decade has witnessed heightened widespread use of stem cell terminology in association with durable T cell responses to infection, antitumor immunity, and autoimmunity. Interpreting this literature is complicated by the fact that descriptions are diverse and criteria for labeling 'stem-like' T cells are evolving. Working under the hypothesis that conceptual frameworks developed for actual stem cells can be used to better evaluate and organize T cells described to have stem-like features, we outline widely accepted properties of stem cells and compare these to different 'stem-like' CD4 T cell populations.
哺乳动物干细胞调控着发育、组织稳态和再生。经过多年的研究，其功能已被日益精确地描绘出来。在过去的十年中，人们广泛使用干细胞术语来描述感染、抗肿瘤免疫和自身免疫中持久的 T 细胞反应。由于描述方式多种多样，并且标记“类干细胞”T 细胞的标准也在不断发展，因此解读这些文献变得很复杂。基于这样一个假设，即针对实际干细胞开发的概念框架可以用于更好地评估和组织具有类干细胞特征的 T 细胞的描述，我们概述了干细胞的广泛公认特性，并将这些特性与不同的“类干细胞”CD4 T 细胞群进行了比较。
