Prashanth B R, Revankar Bhoomika, Karale Rupali, Moogi Prashant P, Mangala M G, Sahoo Amaresh Kumar
Department of Conservative Dentistry and Endodontics, KLE Society's Institute of Dental Sciences, Bangalore, India.
Department of Conservative Dentistry and Endodontics, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
J Conserv Dent Endod. 2024 Jan;27(1):17-23. doi: 10.4103/JCDE.JCDE_138_23. Epub 2024 Jan 13.
The antimicrobial potential of conventional medicaments is reduced due to their limited permeability. The use of calcium hydroxide (CH) is known to reduce the root strength. Nano intracanal medicaments have the following advantages over conventional such as higher surface area and chemical reactivity, and due to its nanosize, have better penetrability, supporting its possible use as an intracanal medicament. Nano versions of CH, chitosan (CS), CS + CH, curcumin (T), and its conventional forms are used in our study.
The aim of this study was to evaluate and compare the depth of penetration of nanosized intracanal medicaments and their effect on fracture resistance of root dentin.
Eighty extracted single-rooted teeth were used after decoronation. Canals were enlarged up to size 30 (0.04° taper) using Neoendo instruments (Orikam, India). Teeth were randomly assigned to two broad groups based on the type of intracanal medicament used; Group A: control (conventional) ( = 40) and Group B: nanosized intracanal medicaments ( = 40). Each group was subdivided into four experimental groups ( = 10), Group A1: CH, Group A2: CS, Group A3: curcumin (T), Group A4: CS + CH, Group B1: nano calcium hydroxide (NCH), Group B2: nano CS (NCS), Group B3: nano curcumin (NT), and Group B4: NCS + nano calcium hydroxide (NCS + NCH). All the specimens were stored in a humidor at 37°C for 4 weeks. Out of 10 specimens from each group, five specimens were used for evaluating the depth of penetration using a confocal laser scanning electron microscope, and the remaining five specimens were used for evaluating fracture resistance in a universal testing machine at the end of 4 weeks. Data were analyzed using one-way ANOVA and intergroup comparison using Tukey's post hoc multiple comparison test.
The highest fracture resistance was seen with NCS and the maximum depth of penetration with nano calcium hydroxide (NCH).
The fracture resistance and depth of penetration at a 4-week interval were higher in nano forms compared to their micro-sized counterparts with all groups. The coronal section presented the highest depth of penetration of intracanal medicaments followed by the middle and least in the apical section of root dentin with all groups.
传统药物的抗菌潜力因其有限的渗透性而降低。已知使用氢氧化钙（CH）会降低牙根强度。纳米根管内药物与传统药物相比具有以下优点，如更高的表面积和化学反应性，并且由于其纳米尺寸，具有更好的渗透性，这支持了其作为根管内药物的可能用途。本研究使用了纳米形式的CH、壳聚糖（CS）、CS + CH、姜黄素（T）及其传统形式。
本研究的目的是评估和比较纳米根管内药物的渗透深度及其对牙根牙本质抗折性的影响。
80颗拔除的单根牙在去冠后使用。使用Neoendo器械（印度Orikam）将根管扩大至30号（0.04°锥度）。根据所使用的根管内药物类型，将牙齿随机分为两大组；A组：对照组（传统药物）（n = 40）和B组：纳米根管内药物（n = 40）。每组再细分为四个实验组（n = 10），A1组：CH，A2组：CS，A3组：姜黄素（T），A4组：CS + CH，B1组：纳米氢氧化钙（NCH），B2组：纳米CS（NCS），B3组：纳米姜黄素（NT），B4组：NCS + 纳米氢氧化钙（NCS + NCH）。所有标本在37°C的保湿器中保存4周。每组10个标本中，5个标本用于使用共聚焦激光扫描电子显微镜评估渗透深度，其余5个标本在4周结束时用于在万能试验机上评估抗折性。数据使用单因素方差分析进行分析，并使用Tukey事后多重比较检验进行组间比较。
NCS的抗折性最高，纳米氢氧化钙（NCH）的渗透深度最大。
与所有组的微米级对应物相比，纳米形式在4周间隔时的抗折性和渗透深度更高。所有组中，根管内药物在牙本质冠部的渗透深度最高，其次是中部，在根尖部最小。
