Pakyntein Mayakiru, Chakraborty Suchismita, Kataki Rubi, Deka Adrija, Roy Debosmita, Borah Diganta
Conservative Dentistry and Endodontics, Regional Dental College, Guwahati, IND.
Cureus. 2025 Aug 1;17(8):e89192. doi: 10.7759/cureus.89192. eCollection 2025 Aug.
The use of calcium hydroxide (CH) is crucial in the proper disinfection of root canals. However, CH affects the fracture resistance of root dentine and also has limited permeability. Nano-based intracanal medicaments have several benefits over traditional medicaments, including a greater surface area-to-volume ratio and better penetrability. Therefore, this in vitrostudy was performed to evaluate and compare the effect of conventional CH and various nanoparticle-based intracanal medicaments on the penetration and fracture resistance of radicular dentin.
One hundred samples were taken and randomly divided into four (n=20) experimental groups (nano-CH (NCH), nano-chitosan (NCS), NCH + nano-silver (NAg), NCS + NAg, and a control group (CH). At the end of one month, out of the 20 samples from each group, 10 samples were used to assess the fracture resistance in a universal testing machine, and the other 10 samples were used to determine the depth of penetration using a field emission scanning electron microscope.
The mean fracture resistance of root dentin value was the highest with group II (NCS) and the least in the control group (CH), which was statistically significant. The maximum penetration depth of intracanal medicaments was observed with group III (NCH + NAg) and the least in the control group (CH), which was statistically significant. Among the thirds of the root samples, the highest mean depth of penetration was seen in the coronal third and the least in the apical third in all the groups, which was statistically significant.
The resistance to fracture and penetration depth at a four‑week interval were higher in nano forms when compared with conventional CH.
氢氧化钙（CH）的使用对根管的适当消毒至关重要。然而，CH会影响牙根牙本质的抗折性，并且其渗透性也有限。与传统药物相比，纳米基根管内药物有诸多益处，包括更大的表面积与体积比以及更好的穿透性。因此，进行了这项体外研究，以评估和比较传统CH与各种纳米颗粒基根管内药物对根管牙本质穿透性和抗折性的影响。
采集100个样本并随机分为四个（n = 20）实验组（纳米CH（NCH）、纳米壳聚糖（NCS）、NCH + 纳米银（NAg）、NCS + NAg）和一个对照组（CH）。在一个月末，从每组的20个样本中，10个样本用于在万能试验机上评估抗折性，另外10个样本用于使用场发射扫描电子显微镜确定穿透深度。
第二组（NCS）牙根牙本质的平均抗折性值最高，对照组（CH）最低，具有统计学意义。根管内药物的最大穿透深度在第三组（NCH + NAg）中观察到，对照组（CH）中最低，具有统计学意义。在牙根样本的三分之一中，所有组在冠部三分之一处的平均穿透深度最高，在根尖三分之一处最低，具有统计学意义。
与传统CH相比，纳米形式在四周间隔时的抗折性和穿透深度更高。
