Ray Sudipta, Sil Susmita, Kannan Muthukumar, Periyasamy Palsamy, Buch Shilpa
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
Adv Drug Alcohol Res. 2023 Mar 3;3:11092. doi: 10.3389/adar.2023.11092. eCollection 2023.
Drug abuse and related disorders are a global public health crisis affecting millions, but to date, limited treatment options are available. Abused drugs include but are not limited to opioids, cocaine, nicotine, methamphetamine, and alcohol. Drug abuse and human immunodeficiency virus-1/acquired immune deficiency syndrome (HIV-1/AIDS) are inextricably linked. Extensive research has been done to understand the effect of prolonged drug use on neuronal signaling networks and gut microbiota. Recently, there has been rising interest in exploring the interactions between the central nervous system and the gut microbiome. This review summarizes the existing research that points toward the potential role of the gut microbiome in the pathogenesis of HIV-1-linked drug abuse and subsequent neuroinflammation and neurodegenerative disorders. Preclinical data about gut dysbiosis as a consequence of drug abuse in the context of HIV-1 has been discussed in detail, along with its implications in various neurodegenerative disorders. Understanding this interplay will help elucidate the etiology and progression of drug abuse-induced neurodegenerative disorders. This will consequently be beneficial in developing possible interventions and therapeutic options for these drug abuse-related disorders.
药物滥用及相关障碍是一场影响数百万人的全球公共卫生危机，但迄今为止，可用的治疗选择有限。滥用药物包括但不限于阿片类药物、可卡因、尼古丁、甲基苯丙胺和酒精。药物滥用与人类免疫缺陷病毒1型/获得性免疫缺陷综合征（HIV-1/AIDS）有着千丝万缕的联系。人们已经进行了广泛的研究，以了解长期吸毒对神经元信号网络和肠道微生物群的影响。最近，探索中枢神经系统与肠道微生物组之间的相互作用的兴趣日益浓厚。这篇综述总结了现有研究，这些研究表明肠道微生物组在与HIV-1相关的药物滥用以及随后的神经炎症和神经退行性疾病的发病机制中可能发挥的作用。本文详细讨论了在HIV-1背景下药物滥用导致肠道微生物群失调的临床前数据，以及其在各种神经退行性疾病中的影响。了解这种相互作用将有助于阐明药物滥用所致神经退行性疾病的病因和进展。因此，这将有利于为这些与药物滥用相关的疾病开发可能的干预措施和治疗选择。
