Laboratory for Algae Biotechnology & Innovation, College of Engineering, Peking University, Beijing 100871, China.
Key Laboratory of Poyang Lake Environment and Resource Utilization, Ministry of Education, Center for Algae Innovation & Engineering Research, School of Resources and Environment, Nanchang University, Nanchang 330031, China.
Mar Drugs. 2024 Jan 24;22(2):54. doi: 10.3390/md22020054.
In light of the escalating global energy crisis, microalgae have emerged as highly promising producers of biofuel and high-value products. Among these microalgae, has received significant attention due to its capacity to generate not only triacylglycerol (TAG) but also eicosapentaenoic acid (EPA) and valuable carotenoids. Recent advancements in genetic tools and the field of synthetic biology have revolutionized into a powerful biofactory. This comprehensive review provides an initial overview of the current state of cultivation and utilization of the genus. Subsequently, our review examines the metabolic pathways governing lipids and carotenoids, emphasizing strategies to enhance oil production and optimize carbon flux redirection toward target products. Additionally, we summarize the utilization of advanced genetic manipulation techniques in . Together, the insights presented in this review highlight the immense potential of as a valuable model for biofuels and synthetic biology. By effectively integrating genetic tools and metabolic engineering, the realization of this potential becomes increasingly feasible.
鉴于全球能源危机不断加剧,微藻作为生物燃料和高价值产品的生产者备受关注。在这些微藻中, 因其不仅能产生三酰基甘油(TAG),还能产生二十碳五烯酸(EPA)和有价值的类胡萝卜素而受到广泛关注。遗传工具和合成生物学领域的最新进展使 成为一个强大的生物工厂。本文全面综述了 的培养和利用现状。随后,我们综述了脂质和类胡萝卜素代谢途径,强调了提高油脂产量和优化碳流向目标产物的策略。此外,我们总结了先进遗传操作技术在 中的应用。总之,本文综述了 作为生物燃料和合成生物学有价值模型的巨大潜力。通过有效整合遗传工具和代谢工程,实现这一潜力变得越来越可行。