Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Health Service Center, Okayama University, 2-1-1 Tsushimanaka, Kita-ku, Okayama 700-0082, Japan.
Int J Environ Res Public Health. 2024 Feb 13;21(2):217. doi: 10.3390/ijerph21020217.
Evidence for acute or long-term coronavirus disease 2019 (COVID-19) infection is relatively limited. We aimed to evaluate the impact of COVID-19 infection on health-related quality of life (HRQoL) in the Japanese population. Eligible study participants were 13,365 employees and their dependents who answered questionnaires at baseline and 18 months later and who had at least 6 months of continuous enrolment before and after baseline. Of the 711 study participants who developed COVID-19 infection, 29.0% reported a decline in HRQoL, whereas 25.2% of uninfected participants reported a decline. The adjusted odds ratios (95% confidence intervals) for the association between COVID-19 infection and declines in HRQoL in the age categories of less than 30 years, 30s, 40s, 50s, and 60 years or higher were 0.54 (0.15-1.92), 1.70 (1.03-2.81), 1.14 (0.82-1.57), 1.05 (0.77-1.42), and 0.87 (0.46-1.64), respectively. This study demonstrates a differential association between COVID-19 infection and declines in HRQoL by age group. A 1.7-fold increase in the odds of negative changes in HRQoL was observed in only those in their 30s. Further studies are needed to elucidate differences in the impact of COVID-19 infection on HRQoL between younger people such as those in their 30s and the older population.
有关急性或长期 2019 冠状病毒病（COVID-19）感染的证据相对有限。本研究旨在评估 COVID-19 感染对日本人群健康相关生活质量（HRQoL）的影响。符合条件的研究参与者是在基线和 18 个月后回答问卷且在基线前后至少有 6 个月连续入组的 13365 名员工及其家属。在 711 名发生 COVID-19 感染的研究参与者中，29.0%报告 HRQoL 下降，而未感染参与者中有 25.2%报告 HRQoL 下降。在年龄小于 30 岁、30 多岁、40 多岁、50 多岁和 60 岁及以上的年龄组中，COVID-19 感染与 HRQoL 下降之间的调整比值比（95%置信区间）分别为 0.54（0.15-1.92）、1.70（1.03-2.81）、1.14（0.82-1.57）、1.05（0.77-1.42）和 0.87（0.46-1.64）。本研究表明，COVID-19 感染与 HRQoL 下降之间的关联存在年龄差异。仅在 30 多岁的人群中观察到 HRQoL 负性变化的可能性增加了 1.7 倍。需要进一步研究来阐明 COVID-19 感染对 HRQoL 的影响在年轻人（如 30 多岁的人群）和老年人群之间的差异。
