Jung Kyoung In, Lee Jiyun, Shin Da Young, Park Chan Kee
College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Department of Ophthalmology, Seoul St. Mary's Hospital, Seoul 06591, Republic of Korea.
J Clin Med. 2024 Feb 17;13(4):1138. doi: 10.3390/jcm13041138.
: A relationship between glaucoma and epiretinal membrane (ERM) has been suggested previously. We investigated the association between intraocular pressure (IOP) fluctuation and idiopathic ERM in patients with glaucoma or glaucoma suspect. : Among patients with glaucoma or glaucoma suspect, data from 43 patients with ERM and 41 patients without ERM were reviewed and analyzed in this retrospective study. The long-term fluctuation of IOP was defined based on the standard deviation of IOP across all visits. : Patients with ERM were older and had a higher SD of IOP and a higher proportion of having a history of cataract surgery and greater macular thickness ( = 0.018, 0.049, 0.013, and <0.001, respectively). In multiple logistic regression analysis, the high-IOP-fluctuation group was associated with the presence of ERM ( = 0.047). Among patients with ERM, eyes with stage-3 or -4 ERM had worse visual field defects based on mean deviation than those with stage-1 or -2 ERM ( = 0.025). : Long-term IOP fluctuation was associated with idiopathic ERM in patients with glaucoma or glaucoma suspect. Idiopathic ERM could serve as a biomarker for long-term IOP fluctuation in glaucoma patients, particularly in clinics where measuring long-term IOP fluctuation during the first visit is not feasible due to its time-consuming nature.
此前已有研究表明青光眼与视网膜前膜（ERM）之间存在关联。我们调查了青光眼或疑似青光眼患者的眼压（IOP）波动与特发性ERM之间的关系。：在这项回顾性研究中，我们回顾并分析了43例患有ERM的青光眼或疑似青光眼患者以及41例未患有ERM的患者的数据。IOP的长期波动是根据所有就诊时IOP的标准差来定义的。：患有ERM的患者年龄更大，IOP的标准差更高，白内障手术史的比例更高，黄斑厚度更大（分别为P = 0.018、0.049、0.013和P<0.001）。在多因素逻辑回归分析中，高IOP波动组与ERM的存在相关（P = 0.047）。在患有ERM的患者中，基于平均偏差，3期或4期ERM的眼睛比1期或2期ERM的眼睛视野缺损更严重（P = 0.025）。：青光眼或疑似青光眼患者的长期IOP波动与特发性ERM相关。特发性ERM可作为青光眼患者长期IOP波动的生物标志物，特别是在初次就诊时由于耗时而无法测量长期IOP波动的诊所。
