比较假性剥脱综合征和原发性开角型青光眼的眼后膜患病率和临床特征。

Comparison of the Prevalence and Clinical Characteristics of Epiretinal Membrane in Pseudoexfoliation and Primary Open-angle Glaucoma.

机构信息

Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

出版信息

J Glaucoma. 2021 Sep 1;30(9):859-865. doi: 10.1097/IJG.0000000000001851.

DOI:10.1097/IJG.0000000000001851

PMID:33899808

Abstract

PURPOSE

The purpose of this study was to investigate and compare the prevalence and clinical characteristics of epiretinal membrane (ERM) in patients with pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG).

METHODS

In this retrospective observational study, 211 PXG eyes, 210 age-matched normal eyes, and 220 POAG eyes were included. The presence and staging of ERM (stage 1, 2, and 3 or greater) were independently assessed by 2 observers. Univariate and multivariate linear regression analyses were performed to assess the factors associated with visual field (VF) mean deviation (MD) in PXG eyes.

RESULTS

Among 211 PXG eyes, 40 (19.0%) had an ERM, while 4.1% of POAG and 2.4% of normal eyes had an ERM (P<0.001). Retinal nerve fiber layer thickness (69.4 vs. 70.4 μm, P=0.477) and VF MD (-7.7 vs. -10.4 dB, P=0.098) were not different between POAG and PXG eyes but macular thickness was greater (259.5 vs. 271.5 μm, P=0.006) in PXG eyes than in POAG. Both lower retinal nerve fiber layer thickness (β=0.337, P<0.001) and the presence of an ERM (β=-4.246, P=0.002) were independently associated with worse VF MD in PXG eyes.

CONCLUSIONS

The prevalence of ERM was significantly greater in PXG eyes than in age-matched normal or POAG eyes. The presence of ERM affected VF in PXG eyes.

摘要

目的

本研究旨在调查和比较假性剥脱综合征（PXG）和原发性开角型青光眼（POAG）患者中视网膜内表面膜（ERM）的患病率和临床特征。

方法

在这项回顾性观察研究中，纳入了 211 只 PXG 眼、210 只年龄匹配的正常眼和 220 只 POAG 眼。两名观察者独立评估 ERM（1 期、2 期和 3 期或更高级别）的存在和分期。进行单变量和多变量线性回归分析，以评估与 PXG 眼视野（VF）平均偏差（MD）相关的因素。

结果

在 211 只 PXG 眼中，40 只（19.0%）患有 ERM，而 POAG 眼中有 4.1%，正常眼中有 2.4%患有 ERM（P<0.001）。视网膜神经纤维层厚度（69.4μm 与 70.4μm，P=0.477）和 VF MD（-7.7dB 与-10.4dB，P=0.098）在 POAG 眼和 PXG 眼中没有差异，但 PXG 眼中的黄斑厚度更大（259.5μm 与 271.5μm，P=0.006）。较低的视网膜神经纤维层厚度（β=0.337，P<0.001）和 ERM 的存在（β=-4.246，P=0.002）均与 PXG 眼中更差的 VF MD 独立相关。