Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
J Glaucoma. 2021 Sep 1;30(9):859-865. doi: 10.1097/IJG.0000000000001851.
The purpose of this study was to investigate and compare the prevalence and clinical characteristics of epiretinal membrane (ERM) in patients with pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG).
In this retrospective observational study, 211 PXG eyes, 210 age-matched normal eyes, and 220 POAG eyes were included. The presence and staging of ERM (stage 1, 2, and 3 or greater) were independently assessed by 2 observers. Univariate and multivariate linear regression analyses were performed to assess the factors associated with visual field (VF) mean deviation (MD) in PXG eyes.
Among 211 PXG eyes, 40 (19.0%) had an ERM, while 4.1% of POAG and 2.4% of normal eyes had an ERM (P<0.001). Retinal nerve fiber layer thickness (69.4 vs. 70.4 μm, P=0.477) and VF MD (-7.7 vs. -10.4 dB, P=0.098) were not different between POAG and PXG eyes but macular thickness was greater (259.5 vs. 271.5 μm, P=0.006) in PXG eyes than in POAG. Both lower retinal nerve fiber layer thickness (β=0.337, P<0.001) and the presence of an ERM (β=-4.246, P=0.002) were independently associated with worse VF MD in PXG eyes.
The prevalence of ERM was significantly greater in PXG eyes than in age-matched normal or POAG eyes. The presence of ERM affected VF in PXG eyes.
本研究旨在调查和比较假性剥脱综合征（PXG）和原发性开角型青光眼（POAG）患者中视网膜内表面膜（ERM）的患病率和临床特征。
在这项回顾性观察研究中，纳入了 211 只 PXG 眼、210 只年龄匹配的正常眼和 220 只 POAG 眼。两名观察者独立评估 ERM（1 期、2 期和 3 期或更高级别）的存在和分期。进行单变量和多变量线性回归分析，以评估与 PXG 眼视野（VF）平均偏差（MD）相关的因素。
在 211 只 PXG 眼中，40 只（19.0%）患有 ERM，而 POAG 眼中有 4.1%，正常眼中有 2.4%患有 ERM（P<0.001）。视网膜神经纤维层厚度（69.4μm 与 70.4μm，P=0.477）和 VF MD（-7.7dB 与-10.4dB，P=0.098）在 POAG 眼和 PXG 眼中没有差异，但 PXG 眼中的黄斑厚度更大（259.5μm 与 271.5μm，P=0.006）。较低的视网膜神经纤维层厚度（β=0.337，P<0.001）和 ERM 的存在（β=-4.246，P=0.002）均与 PXG 眼中更差的 VF MD 独立相关。
PXG 眼中 ERM 的患病率明显高于年龄匹配的正常眼或 POAG 眼。ERM 的存在影响 PXG 眼中的 VF。
