Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
J Glaucoma. 2022 Jul 1;31(7):595-601. doi: 10.1097/IJG.0000000000002024. Epub 2022 Mar 29.
Epiretinal membrane (ERM) tended to deteriorate more in pseudoexfoliation eyes with than without glaucoma. Incremental change in central macular thickness (CMT) induced by ERM deterioration affected longitudinal visual function in pseudoexfoliation glaucoma (PXG) eyes.
The aim was to investigate longitudinal changes in the ERM and their association with glaucoma in patients with pseudoexfoliation syndrome (PXS) and to identify factors associated with the changes in ERM and visual field (VF).
One hundred two eyes with PXG and 32 eyes with nonglaucomatous pseudoexfoliation (ngPX) (mean 8.1±2.6 years of follow-up).
Two observers independently assessed the presence and staging of ERM (stages 1, 2, and ≥3) on serial macular images of spectral-domain optical coherence tomography. Clinical characteristics were compared in eyes with ERM (+) and (-) in both groups. The relationship between putative factors and changes in ERM was determined using logistic regression analysis. Prognostic factors of VF worsening were assessed by Cox proportional hazard analysis.
Of the 102 eyes with PXG, 22 (21.6%) had an ERM at baseline; of the latter, 6 eyes deteriorated (all from stage 1 to 2) and 3 eyes with PXG developed new ERM during follow-up. Of the 32 ngPX eyes, 8 (25%) had an ERM at baseline, with none changing over time. The presence of glaucoma was marginally associated with ERM deterioration (odds ratio: 1.061, P =0.064). Incremental change in CMT was the only factor associated with VF progression (hazard ratio: 1.040, P =0.029) in PXG eyes.
ERM tended to deteriorate more in PXS eyes with than without glaucoma. Incremental change in CMT induced by ERM deterioration affected longitudinal visual function in PXG eyes.
前膜（ERM）在伴有青光眼的假性剥脱综合征（PXS）眼中比在不伴青光眼的眼中更容易恶化。ERM 恶化引起的中央黄斑厚度（CMT）的增量变化影响 PXG 眼中的纵向视觉功能。
旨在研究 PXS 患者 ERM 的纵向变化及其与青光眼的关系，并确定与 ERM 和视野（VF）变化相关的因素。
102 只 PXG 眼和 32 只非青光眼性假性剥脱（ngPX）眼（平均随访 8.1±2.6 年）。
两名观察者独立评估了谱域光学相干断层扫描的一系列黄斑图像上 ERM 的存在和分期（1 期、2 期和≥3 期）。比较了两组中 ERM（+）和（-）眼的临床特征。使用逻辑回归分析确定潜在因素与 ERM 变化之间的关系。使用 Cox 比例风险分析评估 VF 恶化的预测因素。
在 102 只 PXG 眼中，22 只（21.6%）在基线时有 ERM；其中，6 只眼恶化（均从 1 期到 2 期），3 只 PXG 眼在随访期间出现新的 ERM。在 32 只 ngPX 眼中，8 只（25%）在基线时有 ERM，且在整个随访期间均无变化。青光眼的存在与 ERM 恶化有一定的相关性（优势比：1.061，P=0.064）。在 PXG 眼中，CMT 的增量变化是唯一与 VF 进展相关的因素（风险比：1.040，P=0.029）。
ERM 在伴有青光眼的 PXS 眼中比在不伴青光眼的眼中更容易恶化。ERM 恶化引起的 CMT 增量变化影响 PXG 眼中的纵向视觉功能。
