Tsubota Laboratory, Inc., Tokyo, Japan.
Department of Ophthalmology, Keio University, School of Medicine, Tokyo, Japan.
Graefes Arch Clin Exp Ophthalmol. 2024 Jul;262(7):2199-2207. doi: 10.1007/s00417-024-06426-9. Epub 2024 Feb 26.
Herein, we propose the use of the "KeraVio Ring", which is a portable, selfie-based, smartphone-attached corneal topography system that is based on the Placido ring videokeratoscope. The goal of this study was to evaluate and compare corneal parameters between KeraVio Ring and conventional corneal tomography images.
We designed the KeraVio Ring as a device comprising 3D-printed LED rings for generating Placido rings that can be attached to a smartphone. Two LED rings are attached to a cone-shaped device, and both corneas are illuminated. Selfies were taken using the KeraVio Ring attached to the smartphone without assistance from any of the examiners. Captured Placido rings on the cornea were analysed by intelligent software to calculate corneal parameters. Patients with normal, keratoconus, or LASIK-treated eyes were included. Anterior segment optical coherence tomography (AS-OCT) was also performed for each subject.
We found highly significant correlations between the steepest and flattest keratometry, corneal astigmatism, and vector components obtained with the KeraVio Ring and AS-OCT. In subjects with normal, keratoconus, and LASIK-treated eyes, the mean difference in corneal astigmatism between the two devices was -0.8 ± 1.4 diopters (D) (95% limits of agreement (LoA), -3.6 to 2.0), -1.8 ± 3.7 D (95% LoA, -9.1 to 5.5), and -1.5 ± 1.3 D (95% LoA, -4.0 to 1.1), respectively.
The experimental results showed that the corneal parameters obtained by the KeraVio Ring were correlated with those obtained with AS-OCT. The KeraVio Ring has the potential to address an unmet need by providing a tool for portable selfie-based corneal topography.
在此,我们提出使用“KeraVio Ring”,这是一种基于 Placido 环视频角膜地形图仪的便携式、基于自拍的智能手机附件角膜地形系统。本研究的目的是评估和比较 KeraVio Ring 与传统角膜断层图像的角膜参数。
我们将 KeraVio Ring 设计为一种设备,包括用于生成可附着于智能手机的 Placido 环的 3D 打印 LED 环。两个 LED 环附着在一个锥形装置上,两个角膜都被照亮。使用附着在智能手机上的 KeraVio Ring 拍摄自拍,无需检查人员的任何帮助。智能软件分析角膜上捕获的 Placido 环以计算角膜参数。纳入正常、圆锥角膜和 LASIK 治疗的患者。对每位受试者还进行了眼前节光学相干断层扫描(AS-OCT)。
我们发现 KeraVio Ring 和 AS-OCT 获得的最陡和最平角膜曲率、角膜散光和向量分量之间存在高度显著相关性。在正常、圆锥角膜和 LASIK 治疗的患者中,两种设备之间角膜散光的平均差异分别为-0.8±1.4 屈光度(D)(95% 置信区间(LoA),-3.6 至 2.0)、-1.8±3.7 D(95% LoA,-9.1 至 5.5)和-1.5±1.3 D(95% LoA,-4.0 至 1.1)。
实验结果表明,KeraVio Ring 获得的角膜参数与 AS-OCT 获得的参数相关。KeraVio Ring 有潜力通过提供一种便携式基于自拍的角膜地形学工具来满足未满足的需求。