Savage A P, Gornacz G E, Adrian T E, Ghatei M A, Goodlad R A, Wright N A, Bloom S R
Gut. 1985 Dec;26(12):1353-8. doi: 10.1136/gut.26.12.1353.
The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained to 48 days. Plasma PYY correlates both with crypt cell production rate (CCPR) in the ileum and with plasma enteroglucagon levels. In a second study, PYY or saline was infused over a 12 day period. There were no significant changes in intestinal wet weight or CCPR in any part of the bowel studied. This indicates that it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.
已对小肠切除术后适应性反应与血浆PYY浓度之间的关系进行了研究。75%的近端小肠切除导致术后6天时血浆PYY从28±3.1 pmol/l升高至85±12.3 pmol/l(p<0.001),且这种差异持续至48天。血浆PYY与回肠隐窝细胞产生率(CCPR)以及血浆肠高血糖素水平均相关。在第二项研究中,在12天的时间段内输注PYY或生理盐水。在所研究的肠道任何部位,肠湿重或CCPR均无显著变化。这表明PYY对胃肠道不太可能发挥主要的营养作用。