Yamagishi F, Homma N, Haruta K, Iwatsuki K, Chiba S
Jpn J Pharmacol. 1985 Oct;39(2):131-6. doi: 10.1254/jjp.39.131.
The effects of synthesized phosphodiesterase inhibitors, DM 9278 and HWA 285, on pancreatic exocrine secretion were investigated in isolated and blood-perfused canine pancreas. Close-arterial injections of DM 9278 (10-300 micrograms) and HWA 285 (300-3000 micrograms) caused dose-dependent increases in the flow rate of pancreatic juice and perfusion blood flow. Bicarbonate concentration in the pancreatic juice stimulated by DM 9278 (300 micrograms) or HWA 285 (3000 micrograms) was significantly higher than that in the resting pancreatic juice, although neither of the compounds affected protein concentrations in the pancreatic juice. In the secretory volume, 100 micrograms of DM 9278 corresponded roughly to 1000 micrograms of HWA 285, 0.1 units of secretin or 0.3 units of pancreozymin. These secretory and vascular effects were not modified by pretreatment with atropine or sulpiride. This study suggests that both DM 9278 and HWA 285 act directly on ductular cells of the pancreas and induce secretion of water and electrolytes.
在离体和血液灌注的犬胰腺中，研究了合成的磷酸二酯酶抑制剂DM 9278和HWA 285对胰腺外分泌的影响。经动脉注射DM 9278（10 - 300微克）和HWA 285（300 - 3000微克）可使胰液流速和灌注血流呈剂量依赖性增加。尽管这两种化合物均不影响胰液中的蛋白质浓度，但由DM 9278（300微克）或HWA 285（3000微克）刺激产生的胰液中碳酸氢盐浓度显著高于静息胰液中的浓度。在分泌量方面，100微克的DM 9278大致相当于1000微克的HWA 285、0.1单位的促胰液素或0.3单位的促胰酶素。这些分泌和血管效应不会因用阿托品或舒必利预处理而改变。本研究表明，DM 9278和HWA 285均直接作用于胰腺的导管细胞并诱导水和电解质的分泌。
