Yamagishi F, Haruta K, Homma N, Iwatsuki K, Chiba S
Arch Int Pharmacodyn Ther. 1985 Feb;273(2):306-13.
The effects of isosorbide dinitrate (ISDN) on pancreatic exocrine secretion were investigated after intravenous administration in the whole animal and after close-arterial administration on the isolated and blood-perfused dog pancreas preparations. ISDN (10-100 micrograms/kg), injected into the femoral vein, caused a dose-dependent increase in flow rate of pancreatic juice and in protein concentration of the pancreatic juice. Close-arterial injections of ISDN (100-1000 micrograms) produced a dose-dependent increase in perfusion blood flow, flow rate of pancreatic juice and protein concentration of the pancreatic juice without affecting its bicarbonate concentration. These vascular and secretory effects were not modified by pretreatment with atropine. From these data, it is suggested that ISDN induces pancreatic enzyme secretion by acting directly on the acinar cells of the pancreas.
在对完整动物静脉给药以及对离体且有血液灌注的犬胰腺制剂进行动脉内给药后，研究了硝酸异山梨酯（ISDN）对胰腺外分泌的影响。经股静脉注射ISDN（10 - 100微克/千克），可使胰液流速和胰液蛋白质浓度呈剂量依赖性增加。动脉内注射ISDN（100 - 1000微克）可使灌注血流量、胰液流速和胰液蛋白质浓度呈剂量依赖性增加，而不影响其碳酸氢盐浓度。这些血管和分泌效应不会因阿托品预处理而改变。根据这些数据，提示ISDN通过直接作用于胰腺腺泡细胞诱导胰腺酶分泌。
