Gordon Elisa J, Lee Jungwha, Kang Raymond, Uriarte Jefferson, Caicedo Juan Carlos
Department of Surgery, and Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, TN.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Transplant Direct. 2024 Feb 26;10(3):e1595. doi: 10.1097/TXD.0000000000001595. eCollection 2024 Mar.
Hispanic patients receive disproportionately fewer kidney transplants (KT) than non-Hispanic White (NHW) patients. In this observational study, we evaluated disparities in completing evaluation steps to KT among Hispanic patients.
Using medical records of Hispanic and NHW patients initiating evaluation at 4 transplant centers from January 2011 to March 2020, we performed sequential Cox models to compare Hispanic versus NHW patients reaching each step of the evaluation process until receiving a KT.
Among all 5197 patients (Hispanic n = 2473; NHW n = 2724) initiating evaluation, Hispanic patients had 8% lower risk to be approved by the kidney pancreas (KP) committee than NHW patients (adjusted hazard ratio [aHR], 0.92; 95% confidence intervals (CI), 0.86-0.98; = 0.015). Among 3492 patients approved by the KP committee, Hispanic patients had 13% lower risk to be waitlisted than NHW patients (aHR, 0.87; 95% CI, 0.81-0.94; = 0.004). Among 3382 patients who were waitlisted, Hispanic patients had 11% lower risk than NHW patients to receive KT (aHR, 0.89; 95% CI, 0.81-0.97; = 0.011). Among all patients initiating evaluation, Hispanic patients had a 16% lower risk than NHW patients to reach KT (aHR, 0.84; 95% CI, 0.76-0.92; = 0.0002).
Our study found that disproportionately fewer Hispanic patients were approved by the KP committee, were waitlisted, and received a KT, particularly a living donor kidney transplant, than NHW patients. Closer oversight of the evaluation process may help patients overcome challenges in access to KT.
西班牙裔患者接受肾移植(KT)的比例远低于非西班牙裔白人(NHW)患者。在这项观察性研究中,我们评估了西班牙裔患者在完成KT评估步骤方面的差异。
利用2011年1月至2020年3月在4个移植中心开始评估的西班牙裔和NHW患者的病历,我们进行了序贯Cox模型,以比较西班牙裔与NHW患者在接受KT之前达到评估过程每个步骤的情况。
在所有5197名开始评估的患者中(西班牙裔n = 2473;NHW n = 2724),西班牙裔患者被肾胰(KP)委员会批准的风险比NHW患者低8%(调整后风险比[aHR],0.92;95%置信区间[CI],0.86 - 0.98;P = 0.015)。在3492名被KP委员会批准的患者中,西班牙裔患者进入等待名单的风险比NHW患者低13%(aHR,0.87;95% CI,0.81 - 0.94;P = 0.004)。在3382名进入等待名单的患者中,西班牙裔患者接受KT的风险比NHW患者低11%(aHR,0.89;95% CI,0.81 - 0.97;P = 0.011)。在所有开始评估的患者中,西班牙裔患者接受KT的风险比NHW患者低16%(aHR,0.84;95% CI,0.76 - 0.92;P = 0.0002)。
我们的研究发现,与NHW患者相比,被KP委员会批准、进入等待名单并接受KT(尤其是活体供肾移植)的西班牙裔患者比例要低得多。对评估过程进行更密切的监督可能有助于患者克服获得KT的挑战。