Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China.
Department of Medical Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, China.
Front Immunol. 2024 Feb 13;15:1347181. doi: 10.3389/fimmu.2024.1347181. eCollection 2024.
Cancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise for combating cancer. As a crucial factor, energy metabolism influences the activation, proliferation, and function of T cells, and thus metabolic reprogramming of T cells is a unique research perspective in cancer immunology. Special conditions within the tumor microenvironment and high-energy demands lead to alterations in the energy metabolism of T cells. In-depth research on the reprogramming of energy metabolism in T cells can reveal the mechanisms underlying tumor immune tolerance and provide important clues for the development of new tumor immunotherapy strategies as well. Therefore, the study of T cell energy metabolism has important clinical significance and potential applications. In the study, the current achievements in the reprogramming of T cell energy metabolism were reviewed. Then, the influencing factors associated with T cell energy metabolism were introduced. In addition, T cell energy metabolism in cancer immunotherapy was summarized, which highlighted its potential significance in enhancing T cell function and therapeutic outcomes. In summary, energy exhaustion of T cells leads to functional exhaustion, thus resulting in immune evasion by cancer cells. A better understanding of reprogramming of T cell energy metabolism may enable immunotherapy to combat cancer and holds promise for optimizing and enhancing existing therapeutic approaches.
癌症是全球范围内导致人类死亡的主要原因之一，而调节癌症免疫疗法中 T 细胞的代谢特性有望对抗癌症。作为一个关键因素，能量代谢影响 T 细胞的激活、增殖和功能，因此 T 细胞的代谢重编程是癌症免疫学中的一个独特研究视角。肿瘤微环境中的特殊条件和高能量需求导致 T 细胞能量代谢发生改变。深入研究 T 细胞能量代谢的重编程可以揭示肿瘤免疫耐受的机制，并为开发新的肿瘤免疫治疗策略提供重要线索。因此，研究 T 细胞能量代谢具有重要的临床意义和潜在应用价值。在这项研究中，回顾了 T 细胞能量代谢重编程的最新研究成果。然后，介绍了与 T 细胞能量代谢相关的影响因素。此外，总结了癌症免疫疗法中的 T 细胞能量代谢，突出了其在增强 T 细胞功能和治疗效果方面的潜在意义。总之，T 细胞能量耗竭导致功能衰竭，从而导致癌细胞的免疫逃逸。更好地了解 T 细胞能量代谢的重编程可能使免疫疗法能够对抗癌症，并有望优化和增强现有的治疗方法。
