Department of Pharmacology, M. M. College of Pharmacy, M. M. Deemed to be University, Mullana, Ambala, 133207, India.
Department of Pharmaceutical Chemistry, Amity University, Gurugram, Haryana, India.
Curr Diabetes Rev. 2024;21(2):e200224227161. doi: 10.2174/0115733998275676240202065952.
Diabetes is a metabolic illness marked by elevated levels of glucose in the bloodstream due to the inadequate production or use of insulin in the body. Diabetes can result in a range of consequences, with the most prevalent being cardiovascular disease, renal failure, vision loss, and limb removal. Natural compounds isolated from different sources, like colostrum, are the most important compounds for the treatment of diabetes. Colostrum is a form of lactation produced by mammals in the first days after giving birth to their offspring, having a rich source of constituents and showing multipharmacological properties. This review was prepared on the basis of a variety of authoritative search databases, including Google Scholar, Scopus, and PubMed. In addition, the publications and other online sources were also included. In the literature search, the terms "colostrum," "diabetes," "uses," "management," "constituent," "composition," "alternative sources," "mechanism of action," "preclinical," "clinical," "marketed formulations," and "patents" were utilized as keywords and collected from last two decades. Colostrum has been utilized as a treatment for a wide variety of illnesses due to its active constituents. A variety of colostrums are available in the market, like goat colostrum, porcine colostrum, sheep colostrum, human colostrum and many more. They have the full potential of nutrients like minerals, vitamins, lactose, essential enzymes, proteins and high concentrations of immunoproteins. Mostly, the colostrums are used for treating diabetes and its complications. Preclinical and clinical studies of metabolic syndrome, especially on diabetes and its complications, were also reported at the National and International levels, which evidently prove that the use of colostrums in the long term can be beneficial for various ailments associated with diabetes. In general, the findings of this review indicate that supplementation with colostrum may hold promise as a novel therapeutic intervention for people who have diabetes and its complications; however, additional research is required to fully understand its mechanisms of action and determine the best possible dosage as well as the time period of supplementation.
糖尿病是一种代谢性疾病，其特征是由于体内胰岛素的产生或利用不足，导致血液中葡萄糖水平升高。糖尿病会导致一系列后果，其中最常见的是心血管疾病、肾衰竭、视力丧失和肢体切除。从不同来源分离出来的天然化合物，如初乳，是治疗糖尿病最重要的化合物。初乳是哺乳动物在产后最初几天分泌的一种乳汁，含有丰富的成分，具有多种药理学特性。本综述是基于各种权威检索数据库，包括 Google Scholar、Scopus 和 PubMed 编写的。此外，还包括出版物和其他在线来源。在文献检索中，使用了“初乳”、“糖尿病”、“用途”、“管理”、“成分”、“组成”、“替代来源”、“作用机制”、“临床前”、“临床”、“市售制剂”和“专利”等术语作为关键词，并从过去二十年中收集了相关信息。由于其活性成分，初乳已被用作治疗各种疾病的方法。市场上有多种初乳，如山羊初乳、猪初乳、绵羊初乳、人初乳等。它们具有矿物质、维生素、乳糖、必需酶、蛋白质和高浓度免疫球蛋白等营养物质的全部潜力。大多数初乳用于治疗糖尿病及其并发症。在国家和国际层面也报告了代谢综合征，特别是糖尿病及其并发症的临床前和临床研究，这显然证明了长期使用初乳对与糖尿病相关的各种疾病有益。总的来说，本综述的研究结果表明，补充初乳可能是治疗糖尿病及其并发症患者的一种有前途的新疗法；然而，还需要进一步的研究来充分了解其作用机制，并确定最佳可能的剂量以及补充的时间周期。
