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白藜芦醇在伤口愈合中作用的研究进展

[Research progress on the role of resveratrol in wound healing].

作者信息

Liu Y, Yang L P, Liu B X, Zhou S, Li M, Jia Q, Yu X J

机构信息

College of Traditional Chinese Medicine, Inner Mongolia Medical University, Hohhot 010110, China.

Department of Dermatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010110, China.

出版信息

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2024 Feb 20;40(2):196-200. doi: 10.3760/cma.j.cn501225-20230802-00034.

DOI:10.3760/cma.j.cn501225-20230802-00034
PMID:38418182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11630223/
Abstract

The difficulty of wound healing in patients is a difficult problem that doctors in all clinical departments may encounter, and there is still no good solution. Resveratrol is a kind of natural active substance, which has anti-inflammatory, antioxidant, antibacterial, and angiogenesis promoting effects, and is a potential drug to promote wound healing. However, the clinical application of resveratrol is limited due to its low bioavailability. In this review, the molecular mechanism of resveratrol in promoting wound healing and its administration methods in wound treatment were reviewed to provide ideas for the redevelopment of resveratrol.

摘要

患者伤口愈合困难是所有临床科室医生都可能遇到的难题,目前仍没有很好的解决办法。白藜芦醇是一种天然活性物质,具有抗炎、抗氧化、抗菌和促进血管生成的作用,是一种促进伤口愈合的潜在药物。然而,白藜芦醇由于生物利用度低,其临床应用受到限制。本文综述了白藜芦醇促进伤口愈合的分子机制及其在伤口治疗中的给药方法,为白藜芦醇的再开发提供思路。

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1
[Research progress on the role of resveratrol in wound healing].白藜芦醇在伤口愈合中作用的研究进展
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2
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本文引用的文献

1
Effects of four polyphenols on mouse wound healing and the gene expression profile of resveratrol action.四种多酚对小鼠伤口愈合的影响及白藜芦醇作用的基因表达谱。
Histol Histopathol. 2024 Jan;39(1):105-116. doi: 10.14670/HH-18-616. Epub 2023 Apr 3.
2
Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice.白藜芦醇通过诱导糖尿病小鼠 M2 巨噬细胞极化加速伤口愈合。
Pharm Biol. 2022 Dec;60(1):2328-2337. doi: 10.1080/13880209.2022.2149821.
3
Microenvironment-Based Diabetic Foot Ulcer Nanomedicine.基于微环境的糖尿病足溃疡纳米医学。
Adv Sci (Weinh). 2023 Jan;10(2):e2203308. doi: 10.1002/advs.202203308. Epub 2022 Nov 24.
4
A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice.一种含有载有白藜芦醇的纳米颗粒和血小板衍生细胞外囊泡的复合水凝胶可促进糖尿病小鼠的伤口愈合。
Acta Biomater. 2022 Dec;154:212-230. doi: 10.1016/j.actbio.2022.10.038. Epub 2022 Oct 27.
5
Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review.白藜芦醇对伤口愈合的新兴作用:全面综述。
Molecules. 2022 Oct 9;27(19):6736. doi: 10.3390/molecules27196736.
6
Resveratrol Enhances Wound Healing in Type 1 Diabetes Mellitus by Promoting the Expression of Extracellular Vesicle-Carried MicroRNA-129 Derived from Mesenchymal Stem Cells.白藜芦醇通过促进间充质干细胞来源的细胞外囊泡携带的 microRNA-129 的表达增强 1 型糖尿病创面愈合。
J Proteome Res. 2022 Feb 4;21(2):313-324. doi: 10.1021/acs.jproteome.1c00248. Epub 2022 Jan 25.
7
Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis.白藜芦醇通过调节 miR-212/CASP8 轴促进皮肤伤口愈合。
Lab Invest. 2021 Oct;101(10):1363-1370. doi: 10.1038/s41374-021-00621-6. Epub 2021 Jul 7.
8
Poly(Vinyl Alcohol) Cryogel Membranes Loaded with Resveratrol as Potential Active Wound Dressings.载白藜芦醇的聚(聚乙烯醇)水凝胶膜作为有潜力的活性创面敷料。
AAPS PharmSciTech. 2021 Mar 14;22(3):109. doi: 10.1208/s12249-021-01976-1.
9
Anti-Inflammatory Action and Mechanisms of Resveratrol.白藜芦醇的抗炎作用及机制。
Molecules. 2021 Jan 5;26(1):229. doi: 10.3390/molecules26010229.
10
Resveratrol enhances the antimicrobial effect of polymyxin B on Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance.白藜芦醇增强多黏菌素 B 对多黏菌素 B 耐药肺炎克雷伯菌和大肠埃希菌的抗菌作用。
BMC Microbiol. 2020 Oct 12;20(1):306. doi: 10.1186/s12866-020-01995-1.