Desmond M E
Anat Rec. 1985 Jun;212(2):195-8. doi: 10.1002/ar.1092120214.
Patten described as neural overgrowth a folding of brain tissue into the ventricles in abnormal human embryos. Intubation of chick embryo brains release cerebrospinal fluid pressure resulting in a similar folding. These folded brains have 2.5 times less tissue volume than control embryos of identical stage. This study shows, with total DNA measurements, that brain cell number is 50% less in folded brains (intubated embryos) as compared to control brain of identical staged embryos.
帕滕将人类异常胚胎中脑组织向脑室的折叠描述为神经组织过度生长。对鸡胚大脑进行插管可释放脑脊液压力，从而导致类似的折叠。这些折叠的大脑组织体积比相同阶段的对照胚胎少2.5倍。这项研究通过总DNA测量表明，与相同阶段对照胚胎的大脑相比，折叠大脑（插管胚胎）中的脑细胞数量减少了50%。
