Schröder S, Böcker W
Appl Pathol. 1985;3(3):140-9.
Described are rare thyroid lesions which either contain mature adipocytes or consist of lipid-rich follicle cells. Of the former, diffuse lipomatosis and adenolipoma of the thyroid are most likely to be derived from heterotopic islands of fat cells included in the gland during embryogenesis. On the other hand, metaplastic origin of fat cells from stromal fibroblasts due to chronic tissue hypoxia is presumed responsible for the presence of fatty tissue in amyloid goiters. Massive steatosis of follicle cells, as seen in the lipid-rich variant of clear cell thyroid adenomas and carcinomas, is, however, claimed to most likely result from metaplastic transformation of neoplastic thyrocytes. Pathomorphological and clinical features of the aforementioned lesions are discussed.
本文描述了罕见的甲状腺病变，这些病变要么含有成熟脂肪细胞，要么由富含脂质的滤泡细胞组成。对于前者，甲状腺弥漫性脂肪瘤病和腺脂肪瘤最有可能起源于胚胎发育过程中腺体中包含的异位脂肪细胞岛。另一方面，由于慢性组织缺氧，基质成纤维细胞向脂肪细胞的化生起源被认为是淀粉样甲状腺肿中脂肪组织存在的原因。然而，在透明细胞甲状腺腺瘤和癌的富含脂质变体中所见的滤泡细胞大量脂肪变性，据称最有可能是肿瘤性甲状腺细胞化生转化的结果。本文讨论了上述病变的病理形态学和临床特征。
