School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211112, China.
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.
Int J Biol Macromol. 2024 Mar;262(Pt 1):130257. doi: 10.1016/j.ijbiomac.2024.130257. Epub 2024 Feb 29.
The genus Schisandra, a member of the Magnoliaceae family, is a well-known tonic traditional Chinese medicine with a long history of traditional medicinal and functional food used in China. Polysaccharides are one of its main active constituents, which have a wide range of bioactivities, such as anti-inflammatory, anti-tumor, neuroprotection, anti-diabetes, hepatoprotection, immunomodulation, and anti-fatigue. In this paper, we review the extraction, isolation, purification, structural characterization, bioactivities, as well as structure-activity relationship of polysaccharides from the genus Schisandra. In conclusion, we hope that this review could provide reference for the subsequent research on structural, bioactivities, development and application of the genus Schisandra polysaccharides.
五味子属（Schisandra），木兰科的一个成员，是一种在中国有悠久历史的传统中药滋补品和功能性食品。多糖是其主要活性成分之一，具有广泛的生物活性，如抗炎、抗肿瘤、神经保护、抗糖尿病、保肝、免疫调节和抗疲劳。本文综述了五味子属多糖的提取、分离、纯化、结构特征、生物活性以及构效关系。总之，我们希望本文的综述能够为后续研究五味子属多糖的结构、生物活性、开发和应用提供参考。
