Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Front Immunol. 2018 Sep 21;9:2104. doi: 10.3389/fimmu.2018.02104. eCollection 2018.
Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family of non-circulating lymphocytes have been identified. These include innate lymphocytes, innate-like T cells and a subset of conventional T cells. Spanning the innate-adaptive spectrum, these tissue-resident lymphocytes carry out specialized functions and cross-talk with other immune cell types to maintain tissue integrity and homeostasis both at the steady state and during pathological conditions. In this review, we provide an overview of the heterogeneous tissue-resident lymphocyte populations, discuss their development, and highlight their functions both in the context of microbial infection and cancer.
淋巴细胞是免疫系统的一个组成部分。传统上，所有的淋巴细胞都被认为在次级淋巴器官之间持续循环，只有在激活时才会流向非淋巴组织。近年来，人们已经鉴定出了一系列不同的非循环淋巴细胞。这些包括先天淋巴细胞、先天样 T 细胞和一部分常规 T 细胞。这些组织驻留淋巴细胞跨越先天-适应性范围，执行专门的功能，并与其他免疫细胞类型进行交流，以在稳态和病理条件下维持组织完整性和内稳态。在这篇综述中，我们提供了一个异质的组织驻留淋巴细胞群体的概述，讨论了它们的发展，并强调了它们在微生物感染和癌症背景下的功能。
