School of Medicine, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom.
Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom.
Curr Cardiol Rev. 2024;20(3):45-62. doi: 10.2174/011573403X276647240217112151.
There is limited systematic data on the association between the Hospital Frailty Risk Score (HFRS) and characteristics and mortality in patients with cerebrovascular and cardiovascular disease (CVD). This systematic review aimed to summarise the use of the HFRS in describing the prevalence of frailty in patients with CVD, the clinical characteristics of patients with CVD, and the association between frailty on the likelihood of mortality in patients with CVD.
A systematic literature search for observational studies using terms related to CVD, cerebrovascular disease, and the HFRS was conducted using 6 databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were appraised using the Newcastle-Ottawa Scale (NOS).
Seventeen observational studies were included, all rated 'good' quality according to the NOS. One study investigated 5 different CVD cohorts (atrial fibrillation (AF), heart failure (HF), hypotension, hypertension, and chronic ischemic heart disease), 1 study investigated 2 different CVD cohorts (AF and acute myocardial infarction (AMI)), 6 studies investigated HF, 3 studies investigated AMI, 4 studies investigated stroke, 1 study investigated AF, and 1 study investigated cardiac arrest. Increasing frailty risk category was associated with increased age, female sex, and non-white racial group across all CVD. Increasing frailty risk category is also associated with increased length of hospital stay, total costs, and increased odds of 30-day all-cause mortality across all CVD.
The HFRS is an efficient and effective tool for stratifying frailty in patients with CVD and predicting adverse health outcomes.
关于医院衰弱风险评分（HFRS）与脑血管病和心血管病（CVD）患者的特征和死亡率之间的关系，系统数据有限。本系统评价旨在总结 HFRS 在描述 CVD 患者衰弱发生率、CVD 患者临床特征以及衰弱与 CVD 患者死亡率之间的相关性方面的应用。
根据循证医学系统评价和荟萃分析的首选报告项目，使用与 CVD、脑血管疾病和 HFRS 相关的术语，对 6 个数据库进行了系统的文献搜索。使用纽卡斯尔-渥太华量表（NOS）对研究进行评估。
共纳入 17 项观察性研究，根据 NOS 均评为“良好”质量。一项研究调查了 5 种不同的 CVD 队列（房颤（AF）、心力衰竭（HF）、低血压、高血压和慢性缺血性心脏病），1 项研究调查了 2 种不同的 CVD 队列（AF 和急性心肌梗死（AMI）），6 项研究调查了 HF，3 项研究调查了 AMI，4 项研究调查了中风，1 项研究调查了 AF，1 项研究调查了心脏骤停。所有 CVD 中，衰弱风险类别增加与年龄增加、女性和非白色种族群体相关。衰弱风险类别增加也与住院时间延长、总费用增加以及 30 天全因死亡率增加相关。
HFRS 是一种有效且有效的工具，可用于对 CVD 患者进行衰弱分层，并预测不良健康结局。
