衰弱与心血管死亡率：叙事性综述。
Frailty and Cardiovascular Mortality: A Narrative Review.
机构信息
Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Section of Cardiovascular Medicine, Boston Medical Center, Boston University School of Medicine, Boston, USA.
出版信息
Curr Cardiol Rep. 2023 Apr;25(4):249-259. doi: 10.1007/s11886-023-01847-0. Epub 2023 Feb 16.
Abstract
PURPOSE OF REVIEW
The goal of the narrative review is to provide an overview of the epidemiology of frailty in cardiovascular disease and cardiovascular mortality and discuss applications of frailty in cardiovascular care of older adults.
RECENT FINDINGS
Frailty is highly prevalent in older adults with cardiovascular disease and is a robust, independent predictor of cardiovascular death. There is a growing interest in using frailty to inform management of cardiovascular disease either through pre- or post-treatment prognostication or by delineating treatment heterogeneity in which frailty serves to distinguish patients with differential harms or benefits from a given therapy. Frailty can enable more individualized treatment in older adults with cardiovascular disease. Future studies are needed to standardize frailty assessment across cardiovascular trials and enable implementation of frailty assessment in cardiovascular clinical practice.
摘要
目的综述
本综述旨在概述心血管疾病和心血管死亡率方面的虚弱症流行病学，并讨论虚弱症在老年人心血管护理中的应用。
最新发现
虚弱症在患有心血管疾病的老年人中非常普遍，是心血管死亡的一个强有力的独立预测因素。人们越来越感兴趣地使用虚弱症来为心血管疾病的管理提供信息，无论是通过治疗前或治疗后预后，还是通过描述治疗异质性，虚弱症可以区分患者对特定治疗的不同危害或获益。虚弱症可以使老年心血管疾病患者的治疗更加个体化。未来的研究需要标准化心血管试验中的虚弱评估，并在心血管临床实践中实施虚弱评估。
相似文献
1
Frailty and Cardiovascular Mortality: A Narrative Review.衰弱与心血管死亡率：叙事性综述。
Curr Cardiol Rep. 2023 Apr;25(4):249-259. doi: 10.1007/s11886-023-01847-0. Epub 2023 Feb 16.
2
Frailty as a Risk Factor for Cardiovascular Versus Noncardiovascular Mortality in Older Men: Results From the MrOS Sleep (Outcomes of Sleep Disorders in Older Men) Study.衰弱作为老年男性心血管与非心血管死亡率的风险因素：来自 MrOS 睡眠研究（老年男性睡眠障碍结局研究）的结果。
J Am Heart Assoc. 2018 May 4;7(10):e008974. doi: 10.1161/JAHA.118.008974.
3
Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases.老年无心血管疾病人群的衰弱前期表型与动脉僵硬度。
Int J Environ Res Public Health. 2022 Oct 18;19(20):13469. doi: 10.3390/ijerph192013469.
4
Exploring Frailty in the Intersection of Cardiovascular Disease and Cancer in Older People.探讨老年人中心血管疾病与癌症交汇处的脆弱性。
Int J Environ Res Public Health. 2023 Nov 23;20(23):7105. doi: 10.3390/ijerph20237105.
5
Frailty Index Developed From a Cancer-Specific Geriatric Assessment and the Association With Mortality Among Older Adults With Cancer.基于癌症特异性老年评估开发的虚弱指数与老年癌症患者死亡率的相关性。
J Natl Compr Canc Netw. 2017 Jul;15(7):894-902. doi: 10.6004/jnccn.2017.0122.
6
Frailty is highly prevalent in specific cardiovascular diseases and females, but significantly worsens prognosis in all affected patients: A systematic review.衰弱在特定心血管疾病和女性中高度普遍，但在所有受影响的患者中显著恶化预后：系统评价。
Ageing Res Rev. 2021 Mar;66:101233. doi: 10.1016/j.arr.2020.101233. Epub 2020 Dec 14.
7
Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis.虚弱及准虚弱老年人患心血管疾病的发病和死亡风险：一项荟萃分析及探索性Meta回归分析的结果
Ageing Res Rev. 2017 May;35:63-73. doi: 10.1016/j.arr.2017.01.003. Epub 2017 Jan 28.
8
Multimorbidity Patterns, Frailty, and Survival in Community-Dwelling Older Adults.社区居住的老年人中的多病共存模式、虚弱和生存。
J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1265-1270. doi: 10.1093/gerona/gly205.
9
The Role of Frailty in Failure to Rescue After Cardiovascular Surgery.衰弱在心血管手术后抢救失败中的作用。
Ann Thorac Surg. 2021 Feb;111(2):472-478. doi: 10.1016/j.athoracsur.2020.06.065. Epub 2020 Aug 29.
10
Frailty predictors and outcomes among older patients with cardiovascular disease: Data from Fragicor.老年心血管疾病患者的衰弱预测因素及预后：来自Fragicor的数据。
Arch Gerontol Geriatr. 2015 Jul-Aug;61(1):1-7. doi: 10.1016/j.archger.2015.03.001. Epub 2015 Mar 14.
引用本文的文献
1
Association of Preoperative Frailty and Post-Induction Hypotension in Elderly Patients Undergoing Major Non-Cardiac Surgery: A Prospective Observational Cohort Study.老年患者非心脏大手术术前衰弱与诱导后低血压的关联：一项前瞻性观察队列研究
Clin Interv Aging. 2025 Aug 15;20:1283-1292. doi: 10.2147/CIA.S535277. eCollection 2025.
2
Low ALT levels and a new diagnosis of congestive heart failure following COVID-19 infection.新冠病毒感染后谷丙转氨酶水平低以及新发充血性心力衰竭诊断
Front Cardiovasc Med. 2025 Aug 5;12:1470239. doi: 10.3389/fcvm.2025.1470239. eCollection 2025.
3
Optimizing Cardiovascular Care in Aging Populations: A Comprehensive Review of Geriatric Cardiology.优化老年人群的心血管护理：老年心脏病学综合综述
Cureus. 2025 Jul 15;17(7):e87992. doi: 10.7759/cureus.87992. eCollection 2025 Jul.
4
Frailty Predicts Mortality and Procedural Performance in Patients With Non-Variceal Upper Gastrointestinal Bleeding.衰弱可预测非静脉曲张性上消化道出血患者的死亡率和手术操作表现。
JGH Open. 2025 May 21;9(5):e70188. doi: 10.1002/jgh3.70188. eCollection 2025 May.
5
Association between oral health status and frailty in older adults: a systematic review and meta-analysis.老年人口腔健康状况与衰弱之间的关联：一项系统评价和荟萃分析。
Front Public Health. 2025 Mar 31;13:1514623. doi: 10.3389/fpubh.2025.1514623. eCollection 2025.
6
Frailty Associated with Cardiovascular Mortality in Hemodialysis Patients.血液透析患者中与心血管死亡率相关的衰弱
Acta Cardiol Sin. 2025 Mar;41(2):219-229. doi: 10.6515/ACS.202503_41(2).20241111B.
7
Frailty, high-sensitivity C-reactive protein and cardiovascular disease: a nationwide prospective cohort study.衰弱、高敏C反应蛋白与心血管疾病：一项全国性前瞻性队列研究
Aging Clin Exp Res. 2025 Feb 28;37(1):58. doi: 10.1007/s40520-025-02928-6.
8
Interacting and joint effects of frailty and inflammation on cardiovascular disease risk and the mediating role of inflammation in middle-aged and elderly populations.衰弱与炎症对心血管疾病风险的交互作用和联合效应以及炎症在中老年人群中的中介作用
BMC Cardiovasc Disord. 2025 Feb 20;25(1):118. doi: 10.1186/s12872-025-04567-1.
9
Association of frailty with cardiovascular and all-cause mortality in community-dwelling older adults: insights from the Chinese longitudinal healthy longevity survey.社区居住老年人中衰弱与心血管疾病及全因死亡率的关联：来自中国老年健康长寿纵向调查的见解
Front Cardiovasc Med. 2024 Dec 23;11:1499099. doi: 10.3389/fcvm.2024.1499099. eCollection 2024.
10
Multidimensional frailty as a predictor of mortality among older adults: a systematic review and meta-analysis.多维脆弱性作为老年人死亡率的预测指标：系统评价和荟萃分析。
BMC Geriatr. 2024 Sep 28;24(1):793. doi: 10.1186/s12877-024-05377-4.
本文引用的文献
1
Epidemiology, Pathophysiology, and Management of Coronary Artery Disease in the Elderly.老年人冠状动脉疾病的流行病学、病理生理学及管理
Int J Angiol. 2022 Aug 25;31(4):244-250. doi: 10.1055/s-0042-1751234. eCollection 2022 Dec.
2
Trends in Use of Oral Anticoagulants in Older Adults With Newly Diagnosed Atrial Fibrillation, 2010-2020.2010-2020 年新诊断心房颤动老年患者口服抗凝药物使用趋势。
JAMA Netw Open. 2022 Nov 1;5(11):e2242964. doi: 10.1001/jamanetworkopen.2022.42964.
3
Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial.达格列净在心力衰竭患者中的疗效和安全性：DELIVER 试验的预先设定分析。
Circulation. 2022 Oct 18;146(16):1210-1224. doi: 10.1161/CIRCULATIONAHA.122.061754. Epub 2022 Aug 27.
4
Frailty Status Modifies the Efficacy of Exercise Training Among Patients With Chronic Heart Failure and Reduced Ejection Fraction: An Analysis From the HF-ACTION Trial.虚弱状态改变了射血分数降低的慢性心力衰竭患者运动训练的疗效：HF-ACTION 试验的分析。
Circulation. 2022 Jul 12;146(2):80-90. doi: 10.1161/CIRCULATIONAHA.122.059983. Epub 2022 May 26.
5
Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction : A Post Hoc Analysis of the DAPA-HF Trial.达格列净在射血分数降低的心力衰竭中根据虚弱状况的疗效和安全性：DAPA-HF 试验的事后分析。
Ann Intern Med. 2022 Jun;175(6):820-830. doi: 10.7326/M21-4776. Epub 2022 Apr 26.
6
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.2022年美国心脏协会/美国心脏病学会/美国心力衰竭学会心力衰竭管理指南：美国心脏病学会/美国心脏协会临床实践指南联合委员会报告
Circulation. 2022 May 3;145(18):e895-e1032. doi: 10.1161/CIR.0000000000001063. Epub 2022 Apr 1.
7
Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Review.老年心血管疾病患者衰弱的干预措施：JACC 现状评论。
J Am Coll Cardiol. 2022 Feb 8;79(5):482-503. doi: 10.1016/j.jacc.2021.11.029.
8
Frailty in patients undergoing percutaneous left atrial appendage closure.经皮左心耳封堵术患者的脆弱性。
Heart Rhythm. 2022 May;19(5):814-821. doi: 10.1016/j.hrthm.2022.01.007. Epub 2022 Jan 11.
9
Association of Rivaroxaban vs Apixaban With Major Ischemic or Hemorrhagic Events in Patients With Atrial Fibrillation.利伐沙班与阿哌沙班治疗房颤患者的主要缺血或出血事件的相关性。
JAMA. 2021 Dec 21;326(23):2395-2404. doi: 10.1001/jama.2021.21222.
10
Frailty and cardiovascular mortality in more than 3 million US Veterans.超过 300 万美国退伍军人的虚弱与心血管死亡率。
Eur Heart J. 2022 Feb 22;43(8):818-826. doi: 10.1093/eurheartj/ehab850.
Zotero 插件