Hailu Kirubel T, Salib Korlos, Savithri Nandeesha Sanath, Kasagga Alousious, Hawrami Chnoor, Ricci Erica, Hamid Pousette
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, Afet Speciality Clinic, Addis Ababa, ETH.
Cureus. 2024 Jan 30;16(1):e53221. doi: 10.7759/cureus.53221. eCollection 2024 Jan.
Among the leading causes of morbidity, disability, and death worldwide are cardiovascular diseases (CVDs). Their risk factors usually include a variety of factors associated with cardiometabolic disorders. Many public health organizations prioritize the prevention of CVDs and encourage people to maintain a healthy lifestyle. It has been shown that fasting and a healthy diet can promote weight loss and improve cardiometabolic health in various animal species. We want to know the impact of fasting on CVDs. The topic is examined in this systematic review. We looked through a wide range of online sources, including PubMed, Cochrane Library, and Google Scholar, to find randomized controlled trials (RCTs) that looked into the connection between CVDs and fasting. We included human research that has been published in English in peer-reviewed publications in the last five years, and then we screened by the title, abstract, and full-text accessibility. We picked the final 10 articles for quality assessment using Cochrane Collaboration's tool for risk-of-bias assessment of RCTs. The findings suggest that fasting is beneficial in lowering the cardiovascular risk of a population. This result holds for all types of fasting used as an intervention in the clinical trials we reviewed. The result is pronounced when fasting regimens are combined with a regular exercise routine. More comprehensive data will come from larger-scale clinical trials and case-control studies, and a thorough examination of all the potential health impacts of fasting is warranted.
心血管疾病（CVDs）是全球发病、致残和死亡的主要原因之一。其风险因素通常包括与心脏代谢紊乱相关的多种因素。许多公共卫生组织将预防心血管疾病列为优先事项，并鼓励人们保持健康的生活方式。研究表明，禁食和健康饮食可以促进多种动物体重减轻并改善心脏代谢健康。我们想了解禁食对心血管疾病的影响。本系统评价对该主题进行了研究。我们查阅了广泛的在线资源，包括PubMed、Cochrane图书馆和谷歌学术，以寻找研究心血管疾病与禁食之间关系的随机对照试验（RCTs）。我们纳入了过去五年在同行评审出版物中以英文发表的人体研究，然后通过标题、摘要和全文可获取性进行筛选。我们使用Cochrane协作网的随机对照试验偏倚风险评估工具挑选了最后10篇文章进行质量评估。研究结果表明，禁食有助于降低人群的心血管风险。这一结果适用于我们所综述的临床试验中用作干预措施的所有类型的禁食。当禁食方案与常规运动相结合时，效果尤为显著。更全面的数据将来自更大规模的临床试验和病例对照研究，对禁食所有潜在健康影响进行全面检查是有必要的。
