Schroder Jéssica D, Falqueto Hugo, Mânica Aline, Zanini Daniela, de Oliveira Tácio, de Sá Clodoaldo A, Cardoso Andréia Machado, Manfredi Leandro Henrique
Medical School, Federal University of Fronteira Sul, UFFS, SC 484 - Km 02, Fronteira Sul, Chapecó, Santa Catarina, 89815-899, Brazil.
Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, UFFS, SC 484 - Km 02, Fronteira Sul, Chapecó, Santa Catarina, Brazil.
J Transl Med. 2021 Jan 6;19(1):3. doi: 10.1186/s12967-020-02687-0.
The increasing prevalence of overweight and obesity among the worldwide population has been associated with a range of adverse health consequences such as Type 2 diabetes and cardiovascular diseases. The metabolic syndrome (MetS) is a cluster of cardiometabolic abnormalities that occur more commonly in overweight individuals. Time-restricted feeding (TRF) is a dietary approach used for weight loss and overall health. TRF may be an option for those subjects who struggle with extreme restriction diets with foods that generally do not belong to an individual's habits.
The purpose of this study was to determine the effect of TRF on body composition and the association of weight loss with metabolic and cardiovascular risks in obese middle-aged women.
A non-randomized controlled clinical trial was performed over 3 months in obese women (TRF group, n = 20, BMI 32.53 ± 1.13 vs. Control n = 12, BMI 34.55 ± 1.20). The TRF protocol adopted was 16 h without any energy intake followed by 8 h of normal food intake.
Anthropometric measurements, body composition, blood biomarkers, cardiovascular risk in 30 years (CVDRisk30y), and quality of life were evaluated at baseline and after the 3 months.
TRF was effective in reducing weight (~ 4 kg), BMI, % of body fat (%BF), waist circumference from baseline without changes in blood biomarkers associated with MetS. TRF promoted a reduction in CVDRisk30y (12%) wich was moderately correlated with %BF (r = 0.62, n = 64, p < 0.001) and %MM (r = - 0.74, n = 64, p < 0.001).
TRF protocol reduces body weight without changes in biomarkers related to MetS. In addition, the anthropometric evaluation that predicts %BF and %MM could be used as an approach to follow individuals engaged in the TRF regimen since they correlate with cardiovascular risk.
全球人口中超重和肥胖的患病率不断上升，这与一系列不良健康后果相关，如2型糖尿病和心血管疾病。代谢综合征（MetS）是一组心脏代谢异常，在超重个体中更为常见。限时进食（TRF）是一种用于减肥和改善整体健康的饮食方法。对于那些难以遵循极端限制饮食（即食用通常不属于个人习惯的食物）的受试者来说，TRF可能是一种选择。
本研究的目的是确定TRF对肥胖中年女性身体成分的影响，以及体重减轻与代谢和心血管风险之间的关联。
对肥胖女性进行了为期3个月的非随机对照临床试验（TRF组，n = 20，BMI 32.53±1.13；对照组，n = 12，BMI 34.55±1.20）。采用的TRF方案是16小时不摄入任何能量，随后8小时正常进食。
在基线和3个月后评估人体测量学指标、身体成分、血液生物标志物、30年心血管风险（CVDRisk30y）和生活质量。
TRF有效地减轻了体重（约4kg）、BMI、体脂百分比（%BF）和腰围，与MetS相关的血液生物标志物没有变化。TRF使CVDRisk30y降低了12%，这与%BF（r = 0.62，n = 64，p < 0.001）和%MM（r = -0.74，n = 64，p < 0.001）呈中度相关。
TRF方案可减轻体重，而与MetS相关的生物标志物没有变化。此外，预测%BF和%MM的人体测量学评估可作为跟踪参与TRF方案个体的一种方法，因为它们与心血管风险相关。
