Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, Kyoto, Japan.
Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
J Diabetes Investig. 2024 Jul;15(7):874-881. doi: 10.1111/jdi.14176. Epub 2024 Mar 1.
AIMS/INTRODUCTION: Diet directly affects glucose metabolism, and eating behavior is influenced by various daily life stressors. This study was conducted to investigate the relationship between common psychosomatic stressors on endocrine hormones and eating behavior in patients with type 2 diabetes.
This cross-sectional study was performed in 40 patients with type 2 diabetes. Resting hormone blood sampling and four self-reported questionnaires were employed.
Patients who scored higher on the 'anger/hostility' (AH) subcategory of the profile of mood state (POMS) questionnaire had significantly higher serum cortisol (β = 0.40, P = 0.01 by least squares adjusted for age and sex). In the eating behavior questionnaire, the subcategories of 'feeling of hunger/satiation' (β = 0.49, P < 0.01) and 'eating as diversion' (β = 0.39, P = 0.03) were associated with higher serum cortisol. Resting morning cortisol levels were higher in participants who rated high on the POMS-AH and in those who reported 'irritated when hungry' and 'tend to eat when irritated or anxious'. Sleep quality showed no association with eating behavior.
Mood state is associated with eating behavior. Anger increases cortisol levels and may lead to compulsive eating. Various forms of hostility are important factors in appetite control and increased cortisol secretion, and can be an impediment to successful dietary self-management in patients with type 2 diabetes. Thus, assessment of mood state and control of negative mood are important therapeutic targets in diabetes management.
目的/引言：饮食直接影响葡萄糖代谢，而进食行为受各种日常生活应激源的影响。本研究旨在探讨 2 型糖尿病患者常见身心应激源与内分泌激素和进食行为之间的关系。
这是一项横断面研究，共纳入 40 例 2 型糖尿病患者。采集静息激素血样并使用 4 种自报告问卷进行评估。
在简明心境问卷（POMS）的“愤怒/敌意”（AH）亚量表评分较高的患者中，血清皮质醇显著升高（经年龄和性别调整的最小二乘均值差β=0.40，P=0.01）。在进食行为问卷中，“饥饿/饱腹感”（β=0.49，P<0.01）和“以进食作为消遣”（β=0.39，P=0.03）亚项与较高的血清皮质醇相关。POMS-AH 评分较高、“饥饿时易生气”和“生气或焦虑时倾向于进食”的患者静息晨皮质醇水平较高。睡眠质量与进食行为无关。
心境状态与进食行为有关。愤怒会增加皮质醇水平，可能导致强迫性进食。各种形式的敌意是控制食欲和增加皮质醇分泌的重要因素，并且可能成为 2 型糖尿病患者成功进行饮食自我管理的障碍。因此，评估心境状态和控制负性情绪是糖尿病管理中的重要治疗目标。
