Wang Meijiao, Gu Huanpeng, Zhai Yingqi, Li Xuanlin, Huang Lin, Li Haichang, Xie Zhijun, Wen Chengping
Research Institute of Chinese Medicine Clinical Foundation and Immunology, School of Basic Medicine Sciences, Zhejiang Chinese Medical University, Binwen Road, Binjiang Dsitrict, Hangzhou, China.
Arthritis Res Ther. 2024 Mar 4;26(1):60. doi: 10.1186/s13075-024-03296-8.
This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE).
We systematically searched PubMed, Cochrane Library, and Embase for observational studies from inception to September 3, 2023, using medical subject headings (MeSH) and keywords. Study quality was assessed using the NOS scale. Statistical analyses were conducted using STATA software (version 14.0). Publication bias was evaluated using funnel plots and Egger's regression.
The meta-analysis incorporated 17 studies, encompassing 45,067,349 individuals with follow-up periods ranging from 0.5 to 2 years. The pooled analysis revealed no significant association between vaccinations and an increased risk of SLE [OR = 1.14, 95% CI (0.86-1.52), I = 78.1%, P = 0.348]. Subgroup analyses indicated that HBV vaccination was significantly associated with an elevated risk of SLE [OR =2.11, 95% CI (1.11-4.00), I = 63.3%, P = 0.02], HPV vaccination was slightly associated with an increased risk of SLE [OR = 1.43, 95% CI (0.88-2.31), I = 72.4%, P = 0.148], influenza vaccination showed no association with an increased risk of SLE [OR = 0.96, 95% CI (0.82-1.12), I = 0.0%, P = 0.559], and COVID-19 vaccine was marginally associated with a decreased risk of SLE [OR = 0.44, 95% CI (0.18-1.21), I = 91.3%, P = 0.118].
This study suggests that vaccinations are not linked to an increased risk of SLE. Our meta-analysis results provide valuable insights, alleviating concerns about SLE risk post-vaccination and supporting further vaccine development efforts.
本荟萃分析旨在探讨疫苗与系统性红斑狼疮（SLE）之间的潜在联系。
我们使用医学主题词（MeSH）和关键词，系统检索了PubMed、Cochrane图书馆和Embase中从创刊至2023年9月3日的观察性研究。使用NOS量表评估研究质量。使用STATA软件（版本14.0）进行统计分析。使用漏斗图和Egger回归评估发表偏倚。
该荟萃分析纳入了17项研究，涵盖45,067,349名个体，随访期为0.5至2年。汇总分析显示，接种疫苗与SLE风险增加之间无显著关联[比值比（OR）=1.14，95%置信区间（CI）（0.86 - 1.52），异质性指数（I）=78.1%，P = 0.348]。亚组分析表明，乙肝疫苗接种与SLE风险升高显著相关[OR = 2.11，95% CI（1.11 - 4.00），I = 63.3%，P = 0.02]，人乳头瘤病毒疫苗接种与SLE风险增加略有相关[OR = 1.43，95% CI（0.88 - 2.31），I = 72.4%，P = 0.148]，流感疫苗接种与SLE风险增加无关联[OR = 0.96，95% CI（0.82 - 1.12），I = 0.0%，P = 0.559]，而新冠疫苗接种与SLE风险降低存在微弱关联[OR = 0.44，95% CI（0.18 - 1.21），I = 91.3%，P = 0.118]。
本研究表明，接种疫苗与SLE风险增加无关。我们的荟萃分析结果提供了有价值的见解，减轻了对接种疫苗后SLE风险的担忧，并支持了进一步的疫苗研发工作。
