一种具有可注射和自愈能力的壳聚糖基抗菌水凝胶。
A chitosan-based antibacterial hydrogel with injectable and self-healing capabilities.
作者信息
Chen Rui, Hao Yanan, Francesco Secundo, Mao Xiangzhao, Huang Wen-Can
机构信息
State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266404 China.
Qingdao Key Laboratory of Food Biotechnology, Qingdao, 266404 China.
出版信息
Mar Life Sci Technol. 2023 Dec 20;6(1):115-125. doi: 10.1007/s42995-023-00211-z. eCollection 2024 Feb.
UNLABELLED
The presence of bacteria directly affects wound healing. Chitosan-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial properties. Here, a double-cross-linking chitosan-based hydrogel with antibacterial, self-healing, and injectable properties is reported. Thiolated chitosan was successfully prepared, and the thiolated chitosan molecules were cross-linked by Ag-S coordination to form a supramolecular hydrogel. Subsequently, the amine groups in the thiolated chitosan covalently cross-linked with genipin to further promote hydrogel formation. In vitro experimental results indicate that hydrogel can release Ag over an extended time, achieving an antibacterial rate of over 99% against and . Due to the reversible and dynamic feature of Ag-S coordination, an antibacterial hydrogel exhibited injectable and self-healing capabilities. Additionally, the hydrogel showed excellent biocompatibility and biodegradability.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s42995-023-00211-z.
未标注
细菌的存在直接影响伤口愈合。基于壳聚糖的水凝胶生物材料是一种解决方案，因为它们具有强大的抗菌性能，在伤口愈合应用中具有优势。在此，报道了一种具有抗菌、自愈和可注射特性的双交联壳聚糖基水凝胶。成功制备了巯基化壳聚糖，巯基化壳聚糖分子通过Ag-S配位交联形成超分子水凝胶。随后，巯基化壳聚糖中的胺基与京尼平共价交联，进一步促进水凝胶形成。体外实验结果表明，水凝胶可在较长时间内释放银，对[具体细菌1]和[具体细菌2]的抗菌率超过99%。由于Ag-S配位的可逆和动态特性，抗菌水凝胶具有可注射和自愈能力。此外，该水凝胶表现出优异的生物相容性和生物降解性。
补充信息
在线版本包含可在10.1007/s42995-023-00211-z获取的补充材料。
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