Wu Chen-Lei, Wang Meng-Fei, Zhou Rong-Yi
Pediatrics Hospital, First Affiliated Hospital of Henan University of Chinese Medicine/College of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China (Zhou R-Y, Email: zhourongyitcm@sina. com).
Zhongguo Dang Dai Er Ke Za Zhi. 2024 Feb 15;26(2):201-206. doi: 10.7499/j.issn.1008-8830.2309039.
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents, and its etiology and pathogenesis are still unclear. Brain is the organ with the largest oxygen consumption in human body and is easily affected by oxidative imbalance. Oxidative stress has become the key research direction for the pathogenesis of ADHD, but there is still a lack of relevant studies in China. Based on the latest research findings in China and overseas, this article reviews the clinical and experimental studies on oxidative stress in ADHD and explores the association of oxidative stress with neurotransmitter imbalance, neuroinflammation, and cell apoptosis in the pathogenesis of ADHD, so as to provide new research ideas for exploring the pathogenesis of ADHD.
注意缺陷多动障碍（ADHD）是儿童和青少年中常见的神经发育障碍，其病因和发病机制仍不清楚。脑是人体耗氧量最大的器官，容易受到氧化失衡的影响。氧化应激已成为ADHD发病机制的关键研究方向，但国内仍缺乏相关研究。本文基于国内外最新研究成果，综述了ADHD氧化应激的临床及实验研究，探讨氧化应激在ADHD发病机制中与神经递质失衡、神经炎症及细胞凋亡的关联，以期为探索ADHD发病机制提供新的研究思路。
