Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
J Antibiot (Tokyo). 2024 May;77(5):272-277. doi: 10.1038/s41429-024-00707-5. Epub 2024 Mar 4.
Two new antimalarial compounds, named prenylpyridones A (1) and B (2), were discovered from the actinomycete cultured material of Streptomyces sp. RBL-0292 isolated from the soil on Hamahiga Island in Okinawa prefecture. The structures of 1 and 2 were elucidated as new iromycin analogs having α-pyridone ring by MS and NMR analyses. Compounds 1 and 2 showed moderate in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC values ranging from 80.7 to 106.7 µM.
从冲绳县滨比嘉岛上的土壤中分离到的链霉菌属 RBL-0292 的放线菌培养物中发现了两种新型抗疟化合物，命名为烯丙基吡啶酮 A（1）和 B（2）。通过 MS 和 NMR 分析，确定了 1 和 2 的结构为具有α-吡啶酮环的新型伊罗米辛类似物。化合物 1 和 2 对氯喹敏感和氯喹耐药的恶性疟原虫株表现出中等体外抗疟活性，IC 值范围为 80.7 至 106.7 μM。
