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人类胎儿脑组织衍生类器官的伦理和法律挑战:在科学、伦理和监管的交汇处。

The ethical and legal challenges of human foetal brain tissue-derived organoids : At the intersection of science, ethics, and regulation.

机构信息

Graduate School of Humanities and Social Sciences, Hiroshima University, Higashi-Hiroshima, Japan.

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.

出版信息

EMBO Rep. 2024 Apr;25(4):1700-1703. doi: 10.1038/s44319-024-00099-5. Epub 2024 Mar 4.

Abstract

The recent generation of brain organoids from human foetal tissue highlights the need for nuanced ethical considerations and international coordination to navigate the complexities of this research and its broader implications for developmental neuroscience and ethical debates. [Image: see text]

摘要

最近一代源自人类胎儿组织的大脑类器官突出表明,需要进行细致入微的伦理考虑和国际协调,以应对这项研究的复杂性及其对发展神经科学和伦理辩论的更广泛影响。[图片:见正文]

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本文引用的文献

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Human fetal brain self-organizes into long-term expanding organoids.人类胎儿大脑自我组织成长期扩展的类器官。
Cell. 2024 Feb 1;187(3):712-732.e38. doi: 10.1016/j.cell.2023.12.012. Epub 2024 Jan 8.
3
Human fetal tissue is critical for biomedical research.人类胎儿组织对于生物医学研究至关重要。
Stem Cell Reports. 2023 Dec 12;18(12):2300-2312. doi: 10.1016/j.stemcr.2023.10.008. Epub 2023 Nov 16.
4
The Ethics of Human Brain Organoid Transplantation in Animals.动物体内人脑类器官移植的伦理问题。
Neuroethics. 2023;16(3):27. doi: 10.1007/s12152-023-09532-3. Epub 2023 Oct 4.
5
The technology, opportunities, and challenges of Synthetic Biological Intelligence.合成生物智能的技术、机遇与挑战。
Biotechnol Adv. 2023 Nov;68:108233. doi: 10.1016/j.biotechadv.2023.108233. Epub 2023 Aug 7.
7
The legal personhood of human brain organoids.人脑类器官的法人资格。
J Law Biosci. 2023 Apr 3;10(1):lsad007. doi: 10.1093/jlb/lsad007. eCollection 2023 Jan-Jun.
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Organoids: a systematic review of ethical issues.类器官:伦理问题的系统综述。
Stem Cell Res Ther. 2022 Jul 23;13(1):337. doi: 10.1186/s13287-022-02950-9.

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