Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
Cell Stem Cell. 2019 Oct 3;25(4):462-472. doi: 10.1016/j.stem.2019.09.002.
Recent demonstrations of human brain organoid transplantation in rodents have accentuated ethical concerns associated with these entities, especially as they relate to potential "humanization" of host animals. Consideration of established scientific principles can help define the realistic range of expected outcomes in such transplantation studies. This practical approach suggests that augmentation of discrete brain functions in transplant hosts is a more relevant ethical question in the near term than the possibility of "conscious" chimeric animals. We hope that this framework contributes to a balanced approach for proceeding with studies involving brain organoid transplantation and other forms of human-animal brain chimeras.
最近在啮齿动物中进行的人类类脑器官移植实验凸显了人们对这些实体的关注，尤其是它们可能使宿主动物“人类化”。对既定科学原则的考量有助于确定此类移植研究中预期结果的实际范围。这种实用方法表明，在短期内，与“有意识”嵌合体动物的可能性相比，在移植宿主中增强离散脑功能是一个更相关的伦理问题。我们希望这个框架有助于在进行涉及类脑器官移植和其他形式的人类-动物脑嵌合体的研究时采取一种平衡的方法。
