Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA; University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, CO, USA; Charles C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
Stem Cell Reports. 2023 Dec 12;18(12):2300-2312. doi: 10.1016/j.stemcr.2023.10.008. Epub 2023 Nov 16.
Human fetal tissue and cells derived from fetal tissue are crucial for biomedical research. Fetal tissues and cells are used to study both normal development and developmental disorders. They are broadly applied in vaccine development and production. Further, research using cells from fetal tissue is instrumental for studying many infectious diseases, including a broad range of viruses. These widespread applications underscore the value of fetal tissue research and reflect an important point: cells derived from fetal tissues have capabilities that cells from other sources do not. In many cases, increased functionality of cells derived from fetal tissues arises from increased proliferative capacity, ability to survive in culture, and developmental potential that is attenuated in adult tissues. This review highlights important, representative applications of fetal tissue for science and medicine.
人类胎儿组织和源自胎儿组织的细胞对于生物医学研究至关重要。胎儿组织和细胞被用于研究正常发育和发育障碍。它们广泛应用于疫苗的开发和生产。此外，使用源自胎儿组织的细胞进行研究有助于研究许多传染病，包括广泛的病毒。这些广泛的应用凸显了胎儿组织研究的价值，并反映了一个重要观点：源自胎儿组织的细胞具有其他来源的细胞所没有的功能。在许多情况下，源自胎儿组织的细胞功能增强源于增殖能力增强、在培养中存活的能力以及在成人组织中减弱的发育潜力。本综述强调了胎儿组织在科学和医学中的重要、有代表性的应用。
