Nagar Lokesh, Gulati Nisha, Saini Annu, Singh Sachin, Gupta Gaurav, MacLoughlin Ronan, Chellappan Dinesh Kumar, Dua Kamal, Dureja Harish
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, India.
Curr Drug Deliv. 2024 Mar 5. doi: 10.2174/0115672018289883240226113353.
Chronic Obstructive Pulmonary Disease (COPD), a chronic lung disease that causes breathing difficulties and obstructs airflow from the lungs, has a significant global health burden and affects millions of people worldwide. The use of pharmaceuticals in COPD treatment is aimed to alleviate symptoms, improve lung function, prevent exacerbations, and enhance the overall quality of life for patients. Nanotechnology holds great promise to alleviate the burden of COPD. The main goal of this review is to present the full spectrum of therapeutics based on nanostructures for the treatment and management of COPD, including nanoparticles, polymeric nanoparticles, polymeric micelles, solid-lipid nanoparticles, liposomes, exosomes, nanoemulsions, nanosuspensions, and niosomes. Nanotechnology is just one of the many areas of research that may contribute to the development of more effective and personalized treatment modalities for COPD patients in the future. Future studies may be focused on enhancing the therapeutic effectiveness of nanocarriers by conducting extensive mechanistic investigations to translate current scientific knowledge for the effective management of COPD with little or no adverse effects.
慢性阻塞性肺疾病（COPD）是一种导致呼吸困难并阻碍肺部气流的慢性肺部疾病，在全球范围内造成了重大的健康负担，影响着数百万人。在COPD治疗中使用药物旨在缓解症状、改善肺功能、预防病情加重，并提高患者的整体生活质量。纳米技术有望减轻COPD的负担。本综述的主要目的是展示基于纳米结构的治疗方法的全貌，用于COPD的治疗和管理，包括纳米颗粒、聚合物纳米颗粒、聚合物胶束、固体脂质纳米颗粒、脂质体、外泌体、纳米乳液、纳米混悬液和非离子表面活性剂囊泡。纳米技术只是众多研究领域之一，未来可能有助于为COPD患者开发更有效和个性化的治疗方式。未来的研究可能集中在通过进行广泛的机制研究来提高纳米载体的治疗效果，以便将当前的科学知识转化为对COPD的有效管理，且几乎没有或没有不良反应。
