College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetable Processing Ministry of Agriculture, Engineering Research Centre for Fruit and Vegetable Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
Beijing DaBeiNong Biotechnology Co., Ltd., Beijing 100193, China.
J Agric Food Chem. 2024 Mar 20;72(11):5784-5796. doi: 10.1021/acs.jafc.3c09717. Epub 2024 Mar 6.
Adherent-invasive plays an important role in the pathogenesis of inflammatory bowel disease. Blocking the adhesion of to intestinal epithelial cells appears to be useful for attenuating inflammatory bowel disease. Lycopene has been reported to have anti-inflammatory and antimicrobial activities. The aim of this study was to test the intervention effect of lycopene on colitis in mice and to investigate the possible mechanism through which lycopene affects the adhesion of to intestinal epithelial cells. Lycopene (12 mg/kg BW) attenuated dextran sulfate sodium (DSS)-induced colitis, decreased the proportion of , and activated the NLR family pyrin domain containing 12 and inactivated nuclear factor kappa B pathways. Furthermore, lycopene inhibited the adhesion of O157:H7 to Caco-2 cells by blocking the interaction between O157:H7 and integrin β1. Lycopene ameliorated DSS-induced colitis by improving epithelial barrier functions and inhibiting adhesion. Overall, these results show that lycopene may be a promising component for the prevention and treatment of colitis.
黏附侵袭性在炎症性肠病的发病机制中起重要作用。阻断黏附侵袭性对肠道上皮细胞的黏附似乎有助于减轻炎症性肠病。番茄红素具有抗炎和抗菌活性。本研究旨在测试番茄红素对小鼠结肠炎的干预作用，并通过研究番茄红素影响黏附侵袭性对肠道上皮细胞黏附的可能机制。番茄红素（12 毫克/千克体重）减轻了葡聚糖硫酸钠（DSS）诱导的结肠炎，降低了黏附侵袭性的比例，并激活了 NLR 家族包含 pyrin 域的 12 种蛋白，同时抑制了核因子 kappa B 途径。此外，番茄红素通过阻断黏附侵袭性与整合素β1 的相互作用抑制 O157:H7 与 Caco-2 细胞的黏附。番茄红素通过改善上皮屏障功能和抑制黏附侵袭性来改善 DSS 诱导的结肠炎。总的来说，这些结果表明，番茄红素可能是预防和治疗结肠炎的有前途的成分。
