Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences (UAMS), 4301 West Markham Street, Slot 611, BIOMED-1, B306, Little Rock, AR, 72205, USA.
Department of Ophthalmology, Harvey & Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
J Neuroinflammation. 2024 Mar 7;21(1):65. doi: 10.1186/s12974-024-03058-y.
Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retinal diseases including diabetic retinopathy, where they may exert both beneficial and detrimental effects on neurovascular function and angiogenesis. Myeloid cells impact the progression of retinal pathologies and recent studies suggest that targeting myeloid cells is a promising therapeutic strategy to mitigate diabetic retinopathy and other ischemic retinal diseases. This review summarizes the recent advances in our understanding of the role of microglia and macrophages in retinal diseases and focuses on the effects of myeloid cells on neurovascular injury and angiogenesis in ischemic retinopathies. We highlight gaps in knowledge and advocate for a more detailed understanding of the role of myeloid cells in retinal ischemic injury to fully unlock the potential of targeting myeloid cells as a therapeutic strategy for retinal ischemia.
髓系细胞包括小胶质细胞和巨噬细胞，通过清除细胞碎片和调节炎症，在视网膜稳态中发挥关键作用。在几种致盲性缺血性视网膜疾病中，这些细胞被激活，包括糖尿病视网膜病变，它们可能对神经血管功能和血管生成产生有益和有害的影响。髓系细胞影响视网膜病变的进展，最近的研究表明，靶向髓系细胞是减轻糖尿病视网膜病变和其他缺血性视网膜疾病的一种有前途的治疗策略。 本综述总结了我们对小胶质细胞和巨噬细胞在视网膜疾病中的作用的最新认识，并重点介绍了髓系细胞对缺血性视网膜病变中神经血管损伤和血管生成的影响。 我们强调了知识上的差距，并主张更详细地了解髓系细胞在视网膜缺血性损伤中的作用，以充分挖掘靶向髓系细胞作为治疗视网膜缺血的一种治疗策略的潜力。
