Xiangya Shool of Stomatology, Central South University, Changsha, Hunan, China.
Xiangya School of Medicine, Central South University, Changsha, Hunan 410083, China.
Int J Biol Macromol. 2024 Apr;264(Pt 2):130708. doi: 10.1016/j.ijbiomac.2024.130708. Epub 2024 Mar 7.
Although conventional root canal treatment offers an effective therapeutic solution, it negatively affects the viability of the affected tooth. In recent years, pulp regeneration technology has emerged as a novel method for treating irreversible pulpitis due to its ability to maintain tooth vitality. The successful implementation of this technique depends on scaffolds and transplantation of exogenous stem cells or recruitment of endogenous stem cells. Accordingly, the three-dimensional structure and viscoelastic characteristics of hydrogel scaffolds, which parallel those of the extracellular matrix, have generated considerable interest. Furthermore, hydrogels support the controlled release of regenerative drugs and to load a wide variety of bioactive molecules. By integrating antibacterial agents into the hydrogel matrix and stimulating an immune response, root canal disinfection can be significantly improved and the rate of pulp regeneration can be accelerated. This review aims to provide an overview of the clinical applications of hydrogels that have been reported in the last 5 years, and offer a comprehensive summary of the different approaches that have been utilized for the optimization of hydrogel scaffolds for pulp regeneration. Advancements and challenges in pulp regeneration using hydrogels treating aged teeth are discussed.
虽然传统的根管治疗提供了一种有效的治疗方法，但它会对受影响的牙齿的活力产生负面影响。近年来，牙髓再生技术作为一种治疗不可逆性牙髓炎的新方法出现，因为它能够保持牙齿活力。该技术的成功实施取决于支架和外源性干细胞的移植或内源性干细胞的募集。因此，与细胞外基质相似的水凝胶支架的三维结构和粘弹性特征引起了极大的兴趣。此外，水凝胶支持再生药物的控释，并可以负载各种生物活性分子。通过将抗菌剂整合到水凝胶基质中并刺激免疫反应，可以显著提高根管消毒效果，并加速牙髓再生。本综述旨在提供过去 5 年中报道的水凝胶在临床应用方面的概述，并全面总结用于优化牙髓再生水凝胶支架的不同方法。讨论了使用水凝胶治疗老年牙齿的牙髓再生的进展和挑战。
