Tayeb Bizhar Ahmed, Kusuma Ikhwan Yuda, Osman Alaa A M, Minorics Renáta
Institute of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary.
Institution of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, 6725 Szeged, Hungary; Pharmacy Study Program, Faculty of Health, Universitas Harapan Bangsa, Purwokerto 53182, Indonesia.
J Integr Med. 2024 Mar;22(2):137-162. doi: 10.1016/j.joim.2024.02.001. Epub 2024 Feb 28.
The field of personalized medicine has gained increasing attention in cancer care, with the aim of tailoring treatment strategies to individual patients for improved outcomes. Herbal medicine, with its long-standing historical use and extensive bioactive compounds, offers a rich source of potential treatments for various diseases, including cancer.
To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer diseases. Additionally, to explore the general characteristics of the studies included in the analysis, focusing on their key features and trends.
A comprehensive literature search was conducted from multiple online databases, including PubMed, Scopus, Web of Science, and CINAHL-EBSCO. The search strategy was designed to identify studies related to personalized cancer medicine and herbal interventions.
Publications pertaining to cancer research conducted through in vitro, in vivo, and clinical studies, employing natural products were included in this review.
Two review authors independently applied inclusion and inclusion criteria, data extraction, and assessments of methodological quality. The quality assessment and biases of the studies were evaluated based on modified Jadad scales. A detailed quantitative summary of the included studies is presented, providing a comprehensive description of their key features and findings.
A total of 121 studies were included in this review for analysis. Some of them were considered as comprehensive experimental investigations both in vitro and in vivo. The majority (n = 85) of the studies included in this review were conducted in vitro, with 44 of them specifically investigating the effects of herbal medicine on animal models. Additionally, 7 articles with a combined sample size of 31,271 patients, examined the impact of herbal medicine in clinical settings.
Personalized medication can optimize the use of herbal medicine in cancer treatment by considering individual patient factors such as genetics, medical history, and other treatments. Additionally, active phytochemicals found in herbs have shown potential for inhibiting cancer cell growth and inducing apoptosis, making them a promising area of research in preclinical and clinical investigations. Please cite this article as: Tayeb BA, Kusuma IY, Osman AAM, Minorics R. Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review. J Integr Med. 2024; 22(2): 137-162.
个性化医疗领域在癌症治疗中受到越来越多的关注，其目的是为个体患者量身定制治疗策略以改善治疗效果。草药医学历史悠久且含有多种生物活性化合物，为包括癌症在内的各种疾病提供了丰富的潜在治疗来源。
概述将草药化合物纳入癌症精准医疗策略的现有知识和证据。此外，探讨分析中纳入研究的一般特征，重点关注其关键特征和趋势。
通过多个在线数据库进行全面的文献检索，包括PubMed、Scopus、Web of Science和CINAHL-EBSCO。检索策略旨在识别与个性化癌症医疗和草药干预相关的研究。
本综述纳入了通过体外、体内和临床研究进行的与癌症研究相关的出版物，这些研究采用了天然产物。
两位综述作者独立应用纳入和排除标准、数据提取以及方法学质量评估。基于改良的雅达量表评估研究的质量和偏倚。对纳入研究进行了详细的定量总结，全面描述了其关键特征和研究结果。
本综述共纳入121项研究进行分析。其中一些被视为全面的体外和体内实验研究。本综述纳入的大多数研究（n = 85）是在体外进行的，其中44项专门研究了草药对动物模型的影响。此外，7篇文章共纳入31271例患者，研究了草药在临床环境中的影响。
个性化用药可通过考虑个体患者因素，如遗传学、病史和其他治疗方法，优化草药在癌症治疗中的应用。此外，草药中发现的活性植物化学物质已显示出抑制癌细胞生长和诱导凋亡的潜力，使其成为临床前和临床研究中一个有前景的研究领域。请将本文引用为：Tayeb BA, Kusuma IY, Osman AAM, Minorics R. 草药化合物作为癌症精准医疗策略中有前景的治疗剂：一项系统综述。《整合医学杂志》。2024年；22(2)：137 - 162。
