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本文引用的文献

1
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS-2020 UPDATE.美国临床内分泌医师协会/美国内分泌学会 2020 年绝经后骨质疏松症诊断和治疗临床实践指南更新版
Endocr Pract. 2020 May;26(Suppl 1):1-46. doi: 10.4158/GL-2020-0524SUPPL.
2
Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update.绝经后妇女骨质疏松症的药物治疗:内分泌学会指南更新。
J Clin Endocrinol Metab. 2020 Mar 1;105(3). doi: 10.1210/clinem/dgaa048.
3
Reducing the treatment gap in osteoporosis.缩小骨质疏松症的治疗差距。
Lancet Diabetes Endocrinol. 2020 Jan;8(1):7-9. doi: 10.1016/S2213-8587(19)30378-X. Epub 2019 Nov 19.
4
Recent Advances in the Genetics of Fractures in Osteoporosis.骨质疏松症骨折遗传学的最新进展
Front Endocrinol (Lausanne). 2019 Jun 4;10:337. doi: 10.3389/fendo.2019.00337. eCollection 2019.
5
On the utilization of polygenic risk scores for therapeutic targeting.关于多基因风险评分在治疗靶点中的应用。
PLoS Genet. 2019 Apr 25;15(4):e1008060. doi: 10.1371/journal.pgen.1008060. eCollection 2019 Apr.
6
Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human.用于发现和鉴定小鼠及人类骨质疏松症相关基因的先进遗传方法
Front Genet. 2019 Apr 2;10:288. doi: 10.3389/fgene.2019.00288. eCollection 2019.
7
The genetic architecture of osteoporosis and fracture risk.骨质疏松症和骨折风险的遗传结构。
Bone. 2019 Sep;126:2-10. doi: 10.1016/j.bone.2019.04.005. Epub 2019 Apr 10.
8
What Are Polygenic Scores and Why Are They Important?多基因评分是什么,为什么它们很重要?
JAMA. 2019 May 14;321(18):1820-1821. doi: 10.1001/jama.2019.3893.
9
Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline.绝经后妇女骨质疏松症的药物治疗:内分泌学会临床实践指南*。
J Clin Endocrinol Metab. 2019 May 1;104(5):1595-1622. doi: 10.1210/jc.2019-00221.
10
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.全基因组捕获 C 启动子相互作用提示 GWAS 骨密度位点的效应基因。
Nat Commun. 2019 Mar 19;10(1):1260. doi: 10.1038/s41467-019-09302-x.

骨质疏松症:筛查、诊断、评估和治疗的最新进展。

Osteoporosis: An Update on Screening, Diagnosis, Evaluation, and Treatment.

出版信息

Orthopedics. 2023 Jan-Feb;46(1):e20-e26. doi: 10.3928/01477447-20220719-03. Epub 2022 Jul 25.

DOI:10.3928/01477447-20220719-03
PMID:35876780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10084730/
Abstract

Osteoporosis screening, diagnosis, and treatment have gained much attention in the health care community over the past 2 decades. During this time, creation of multispecialty awareness programs (eg, "Own the Bone," American Orthopedic Association; "Capture the Fracture," International Osteoporosis Foundation) and improvements in diagnostic protocols have been evident. Significant advances in technology have elucidated elements of genetic predisposition for decreased bone mineral density in the aging population. Additionally, several novel drug therapies have entered the market and provide more options for primary care and osteoporosis specialists to medically manage patients at risk for fragility fractures. Despite this, adherence to osteoporosis screening and treatment protocols has been surprisingly low by health care practitioners, including orthopedic surgeons. Continued awareness and education of this skeletal disorder is crucial to effectively care for our aging population. [. 2023;46(1):e20-e26.].

摘要

在过去的 20 年里,骨质疏松症的筛查、诊断和治疗在医疗保健领域受到了广泛关注。在此期间,多学科意识计划(如“拥有骨骼”,美国骨科协会;“捕捉骨折”,国际骨质疏松基金会)的创建和诊断方案的改进已经很明显。技术的重大进步阐明了老龄化人口中骨密度降低的遗传易感性因素。此外,几种新的药物治疗方法已经进入市场,为初级保健医生和骨质疏松症专家提供了更多的选择,以便对有脆性骨折风险的患者进行医学管理。尽管如此,包括骨科医生在内的医疗保健从业者对骨质疏松症筛查和治疗方案的依从性却低得惊人。持续提高对这种骨骼疾病的认识和教育对于有效照顾我们的老年人口至关重要。[. 2023;46(1):e20-e26.].