• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1例经点刺试验确诊的左氧氟沙星滴眼液致过敏性休克病例

A Case of Anaphylactic Shock Due to Levofloxacin Eye Drops Confirmed by a Prick Test.

作者信息

Ikeda Isamu, Fukushima Satoshi

机构信息

Department of Dermatology, Omuta Tenryo Hospital, Omuta, JPN.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, JPN.

出版信息

Cureus. 2024 Feb 7;16(2):e53804. doi: 10.7759/cureus.53804. eCollection 2024 Feb.

DOI:10.7759/cureus.53804
PMID:38465137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10924633/
Abstract

Topical levofloxacin has been used safely, but it can induce life-threatening hypersensitivities. We report a case of anaphylactic shock caused by levofloxacin eye drops during the treatment of a corneal injury, confirmed by a prick test. Reported cases of hypersensitivity to levofloxacin and its racemate ofloxacin eye drops are also summarized.

摘要

局部用左氧氟沙星一直被安全使用，但它可引发危及生命的超敏反应。我们报告1例在角膜损伤治疗期间由左氧氟沙星滴眼液引起过敏性休克的病例，经点刺试验确诊。还总结了已报道的对左氧氟沙星及其消旋体氧氟沙星滴眼液过敏的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d83/10924633/65412b6f4146/cureus-0016-00000053804-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d83/10924633/65412b6f4146/cureus-0016-00000053804-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d83/10924633/65412b6f4146/cureus-0016-00000053804-i01.jpg

相似文献

1
A Case of Anaphylactic Shock Due to Levofloxacin Eye Drops Confirmed by a Prick Test.1例经点刺试验确诊的左氧氟沙星滴眼液致过敏性休克病例
Cureus. 2024 Feb 7;16(2):e53804. doi: 10.7759/cureus.53804. eCollection 2024 Feb.
2
Concentrations of levofloxacin, ofloxacin, and ciprofloxacin in human corneal stromal tissue and aqueous humor after topical administration.局部给药后左氧氟沙星、氧氟沙星和环丙沙星在人角膜基质组织和房水中的浓度。
Cornea. 2004 Apr;23(3):255-63. doi: 10.1097/00003226-200404000-00007.
3
Anaphylactic shock secondary to oral ofloxacin administration with cross-reactivity to levofloxacin and ciprofloxacin.
Therapie. 2018 Dec;73(6):555-556. doi: 10.1016/j.therap.2018.05.001. Epub 2018 Jun 20.
4
Anaphylaxis due to intravenous levofloxacin with tolerance to garenoxacin.静脉注射左氧氟沙星导致过敏反应，对加替沙星耐受。
Intern Med. 2012;51(13):1769-72. doi: 10.2169/internalmedicine.51.7530. Epub 2012 Jul 1.
5
Corneal plaque containing levofloxacin in a dog.一只狗的含有左氧氟沙星的角膜斑块。
Vet Ophthalmol. 2015 Nov;18(6):521-6. doi: 10.1111/vop.12263. Epub 2015 Feb 24.
6
A case of drug induced lung injury caused by levofloxacin eye drops.1例由左氧氟沙星滴眼液引起的药物性肺损伤病例。
Respir Med Case Rep. 2018 Mar 16;24:12-15. doi: 10.1016/j.rmcr.2018.03.010. eCollection 2018.
7
Eye drops and eye gels of levofloxacin: comparison of ocular absorption characterizations and therapeutic effects in the treatment of bacterial keratitis in rabbits.左氧氟沙星滴眼液和眼用凝胶：眼部吸收特征比较及治疗兔细菌性角膜炎的疗效观察。
Drug Dev Ind Pharm. 2020 Apr;46(4):673-681. doi: 10.1080/03639045.2020.1750626. Epub 2020 Apr 20.
8
Corneal penetration of levofloxacin into the human aqueous humour: a comparison with ciprofloxacin.左氧氟沙星在人房水中的角膜穿透性：与环丙沙星的比较。
Acta Ophthalmol Scand. 2003 Dec;81(6):611-3. doi: 10.1111/j.1395-3907.2003.00173.x.
9
[Levofloxacin (Tavanic) in the treatment of corneal ulcers].左氧氟沙星（可乐必妥）治疗角膜溃疡
Antibiot Khimioter. 2003;48(6):16-9.
10
Fixed-Combination Eye Drops Based on Fluorometholone Nanoparticles and Bromfenac/Levofloxacin Solution Improve Drug Corneal Penetration.基于氟米龙纳米粒和溴芬酸钠/左氧氟沙星溶液的固定剂量复方滴眼剂可改善药物角膜穿透性。
Int J Nanomedicine. 2021 Aug 10;16:5343-5356. doi: 10.2147/IJN.S317046. eCollection 2021.

本文引用的文献

1
Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report.环丙沙星致过敏反应，左氧氟沙星激发试验阴性：1 例报告。
Medicina (Kaunas). 2023 Oct 7;59(10):1784. doi: 10.3390/medicina59101784.
2
Immediate Hypersensitivity to Fluoroquinolones: 
A Cohort Assessing Cross-Reactivity.对氟喹诺酮类药物的速发型超敏反应：一项评估交叉反应性的队列研究
Open Forum Infect Dis. 2022 Mar 2;9(4):ofac106. doi: 10.1093/ofid/ofac106. eCollection 2022 Apr.
3
Quinolone Allergy.喹诺酮类过敏
Pharmacy (Basel). 2019 Jul 19;7(3):97. doi: 10.3390/pharmacy7030097.
4
Anaphylaxis to levofloxacin.对左氧氟沙星过敏。
Allergol Immunopathol (Madr). 2013 Nov-Dec;41(6):418-9. doi: 10.1016/j.aller.2012.09.004. Epub 2012 Dec 21.
5
Contact urticaria syndrome from eye drops: levofloxacin hydrate ophthalmic solution.滴眼液引起的接触性荨麻疹综合征：左氧氟沙星水合物眼药水
J Dermatol. 2013 Feb;40(2):130-1. doi: 10.1111/1346-8138.12019. Epub 2012 Oct 30.
6
Mechanism of histamine release induced by levofloxacin, a fluoroquinolone antibacterial agent.
Eur J Pharmacol. 2000 Apr 7;394(1):51-5. doi: 10.1016/s0014-2999(00)00147-3.