Song Jiangbo, Xiao Li, Zhang Zhehao, Wang Yujin, Kouis Panayiotis, Rasmussen Lene Juel, Dai Fangyin
State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China.
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Front Cell Dev Biol. 2024 Feb 23;12:1347286. doi: 10.3389/fcell.2024.1347286. eCollection 2024.
Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting the energy requirements of cells through the respiratory chain located in the inner mitochondrial membrane, concomitant with the generation of reactive oxygen species (ROS). A wealth of evidence derived from contemporary investigations on reproductive longevity strongly indicates that the aberrant elevation of ROS level constitutes a fundamental factor in hastening the aging process of reproductive systems which are responsible for transmission of DNA to future generations. Constant changes in redox status, with a pro-oxidant shift mainly through the mitochondrial generation of ROS, are linked to the modulation of physiological and pathological pathways in gametes and reproductive tissues. Furthermore, the quantity and quality of mitochondria essential to capacitation and fertilization are increasingly associated with reproductive aging. The article aims to provide current understanding of the contributions of ROS derived from mitochondrial respiration to the process of reproductive aging. Moreover, understanding the impact of mitochondrial dysfunction on both female and male fertility is conducive to finding therapeutic strategies to slow, prevent or reverse the process of gamete aging, and thereby increase reproductive longevity.
线粒体是对细胞和机体生存至关重要的多功能细胞器，通过位于线粒体内膜的呼吸链在满足细胞能量需求方面发挥关键作用，同时产生活性氧（ROS）。来自当代关于生殖寿命研究的大量证据有力地表明，ROS水平的异常升高是加速负责将DNA传递给后代的生殖系统衰老过程的一个基本因素。氧化还原状态的持续变化，主要通过线粒体产生ROS导致促氧化转变，与配子和生殖组织中生理和病理途径的调节有关。此外，获能和受精所必需的线粒体的数量和质量与生殖衰老的关系日益密切。本文旨在阐述目前对线粒体呼吸产生的ROS在生殖衰老过程中的作用的认识。此外，了解线粒体功能障碍对男性和女性生育能力的影响有助于找到减缓、预防或逆转配子衰老过程的治疗策略，从而延长生殖寿命。
