Zhao Lihong, Liu Li, Liu Yehua, Zheng Hong, Jiang Ping
Department of Respiratory and Critical Care Medicine, Tianjin First Central Hospital, Tianjin, 300192, China.
Department of Clinical Laboratory, Tianjin First Central Hospital, Tianjin, 300192, China.
Open Life Sci. 2024 Feb 8;19(1):20220814. doi: 10.1515/biol-2022-0814. eCollection 2024.
Interstitial pneumonia with autoimmune features (IPAF) is a type of interstitial lung disease (ILD) with immune features that do not meet the diagnostic criteria for specific connective tissue diseases (CTDs). This retrospective case-control study investigated the role of serum B-cell-activating factor of the tumor necrosis factor family (BAFF) and interleukin (IL)-17 as biomarkers for IPAF. The differences in serum BAFF, IL-17, and IL-10 were compared among patients with idiopathic pulmonary fibrosis (IPF), IPAF, ILD associated with CTD (CTD-ILD), and healthy controls. The patients were treatment naïve. The correlations of BAFF with IL-10, IL-17, and pulmonary function were analyzed. The classifiable value of BAFF for IPAF was examined. The results showed that the serum levels of BAFF and IL-17 in the IPAF and CTD-ILD groups were higher than in the IPF group. High BAFF levels and high predicted diffusion capacity of the lungs for carbon monoxide (DLCO) were independent predictive factors for IPAF vs IPF. In the IPAF and CTD-ILD groups, serum BAFF levels were negatively correlated with predicted values of forced vital capacity (FVC%) and diffusing capacity of the lungs for carbon monoxide (DLCO%) and positively correlated with serum IL-17 and IL-10 levels. The cutoff value of combined BAFF and IL-17 was 0.704, and the sensitivity and specificity for classifying IPAF were 78.9 and 95.7%, respectively. In conclusion, combining serum BAFF and IL-17 as a biomarker may have classifiable value in differentiating IPAF from other forms of ILD.
具有自身免疫特征的间质性肺炎（IPAF）是一种具有免疫特征但不符合特定结缔组织病（CTD）诊断标准的间质性肺疾病（ILD）。这项回顾性病例对照研究调查了血清肿瘤坏死因子家族B细胞激活因子（BAFF）和白细胞介素（IL）-17作为IPAF生物标志物的作用。比较了特发性肺纤维化（IPF）、IPAF、与CTD相关的ILD（CTD-ILD）患者和健康对照者血清BAFF、IL-17和IL-10的差异。患者均未接受过治疗。分析了BAFF与IL-10、IL-17及肺功能的相关性。检验了BAFF对IPAF的分类价值。结果显示，IPAF组和CTD-ILD组的血清BAFF和IL-17水平高于IPF组。高BAFF水平和高肺一氧化碳弥散量预测值（DLCO）是IPAF与IPF的独立预测因素。在IPAF组和CTD-ILD组中，血清BAFF水平与用力肺活量预测值（FVC%）和肺一氧化碳弥散量（DLCO%）呈负相关，与血清IL-17和IL-10水平呈正相关。BAFF与IL-17联合的截断值为0.704，对IPAF分类的敏感性和特异性分别为78.9%和95.7%。总之，联合血清BAFF和IL-17作为生物标志物在区分IPAF与其他形式ILD方面可能具有分类价值。
