Lv Fantao, Wang Haiyan, Zhang Dawei, Wu Shengwei
Department of Ophthalmology, Beijing Luhe Hospital Capital Medical University, Beijing 101199, China.
Appl Bionics Biomech. 2022 May 9;2022:8523747. doi: 10.1155/2022/8523747. eCollection 2022.
In infective endophthalmitis, once the patient's vision is seriously damaged, the damage to children's vision is particularly serious. The main purpose of this study is to investigate the etiology, epidemiology, treatment, and visual prognosis of children's endophthalmitis and to conduct an in-depth analysis. . This study collected case data from the Beijing Tongren Hospital Capital Medical University in the period from January 1, 2002 to January 1, 2018. The basic conditions for inclusion in the collection range were patients who were less than or equal to 14 years old and had a history of infectious endophthalmitis. A retrospective study and analysis of etiology, epidemiology, treatment, and visual prognosis were performed. Kappa and Chi square test were used for statistical analysis.
A total of 232 cases were collected, with an average age of 6.33 ± 2.89 years (range 8months to 14 years). The most common etiologies were ocular trauma (93.5%) and previous ocular surgery (5.2%). Overall, 81 samples were sent to the microbiology department for direct smear and culture, from which 21 organisms were isolated. 28 cases (39.5%) were culture-positive. The most organism was Gram-positive organisms. In treatment, the proportion of PPV use combined with silicone oil filling had increased gradually in three phases, while the other treatments were almost decreased or nearly similar. The final visual result is 22 (9.5) in 20/200 or better, 65 (28.0) in CF-20/200, 38 (16.4) in hand move (HM), 27 (11.6) in light perception (LP), 21 (9.1) in no light perception (NLP), and 59 (25.4) did not match (NM).
Penetrating ocular trauma is the most common cause of infectious endophthalmitis in children. The detection rate of microorganisms is low and helpless for the treatment. In this study, it was found that despite the aggressive treatments such as antibacterial and vitrectomy, the ultimate improvement in vision was highly undesirable.
在感染性眼内炎中，一旦患者视力严重受损，对儿童视力的损害尤为严重。本研究的主要目的是调查儿童眼内炎的病因、流行病学、治疗方法及视力预后情况，并进行深入分析。本研究收集了首都医科大学附属北京同仁医院2002年1月1日至2018年1月1日期间的病例数据。纳入收集范围的基本条件为年龄小于或等于14岁且有感染性眼内炎病史的患者。对病因、流行病学、治疗方法及视力预后进行回顾性研究和分析。采用Kappa检验和卡方检验进行统计学分析。
共收集到232例病例，平均年龄为6.33±2.89岁（范围为8个月至14岁）。最常见的病因是眼外伤（93.5%）和既往眼部手术（5.2%）。总体而言，81份样本被送至微生物科进行直接涂片和培养，从中分离出21种微生物。28例（39.5%）培养呈阳性。最常见的微生物是革兰氏阳性菌。在治疗方面，玻璃体切割联合硅油填充的使用比例在三个阶段逐渐增加，而其他治疗方法几乎呈下降趋势或基本相似。最终视力结果为：20/200及以上22例（9.5%），CF-20/200 65例（28.0%），手动（HM）38例（16.4%），光感（LP）27例（11.6%），无光感（NLP）21例（9.1%），未匹配（NM）59例（25.4%）。
穿透性眼外伤是儿童感染性眼内炎最常见的病因。微生物的检出率较低，对治疗无助。在本研究中发现，尽管采用了抗菌和玻璃体切割等积极治疗方法，但视力的最终改善情况仍很不理想。
