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非甾体抗炎药(NSAID)诱发一名50岁女性患史蒂文斯-约翰逊综合征:病例研究

NSAID (nonsteroidal anti-inflammatory drugs) Induced Stevens Johnson Syndrome in a 50-year-old woman: A case study.

作者信息

Faraji Navid, Goli Rasoul, Mohsennezhad Pariya, Mohammadpour Yousef, Parizad Naser, Salamat Elaheh, Pourbahram Raheleh, Bazbandi Samaneh

机构信息

Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, Iran.

Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Islamic Azad University, Urmia, Iran.

出版信息

Toxicol Rep. 2024 Feb 28;12:289-291. doi: 10.1016/j.toxrep.2024.02.006. eCollection 2024 Jun.

Abstract

Stevens-Johnson Syndrome (SJS) is a severe and rare adverse drug reaction associated with significant morbidity and mortality. Although SJS is commonly triggered by multiple drugs, non-steroidal anti-inflammatory drugs (NSAIDs), including diclofenac, have been frequently implicated. A middle-aged woman, who is 50 years old, has a prior medical record of high blood pressure, type 2 diabetes, and has recently suffered from a pulmonary embolism. She was later admitted to the intensive care unit (ICU), where she was ultimately diagnosed with Steven Johnson syndrome. Careful drug selection, close monitoring of patients with predisposing factors, and prompt identification of adverse events are crucial to prevent severe drug reactions.

摘要

史蒂文斯-约翰逊综合征(SJS)是一种严重且罕见的药物不良反应,与显著的发病率和死亡率相关。虽然SJS通常由多种药物引发,但非甾体抗炎药(NSAIDs),包括双氯芬酸,经常被牵涉其中。一名50岁的中年女性,既往有高血压、2型糖尿病病史,近期还患有肺栓塞。她后来被收入重症监护病房(ICU),最终在那里被诊断为史蒂文斯-约翰逊综合征。谨慎选择药物、密切监测有易感因素的患者以及及时识别不良事件对于预防严重药物反应至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a652/10925921/4382f634adf4/ga1.jpg

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