Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Endodontic Division, Faculty of Dentistry, Beirut Arab University, Beirut, Lebanon.
Clin Oral Investig. 2024 Mar 14;28(4):213. doi: 10.1007/s00784-024-05612-7.
The limitations of spontaneous bone healing underscore the necessity for exploring alternative strategies to enhance bone regeneration in maxillary radicular cyst cases. This retrospective study aimed to assess the impact of a bone substitute material (i.e., Bio-Oss) on bone volume regeneration following maxillary radicular cyst enucleation using cone-beam computed tomography (CBCT).
Seventy-three patients with maxillary radicular cysts were divided into two groups: one undergoing guided bone regeneration (GBR) with Bio-Oss and absorbable collagen membrane (n = 35), and the other receiving cyst excision alone (n = 38). Volumetric measurements using Amira software on CBCT scans evaluated bone regeneration, with cystic lesion shrinkage rates calculated. Intergroup comparisons utilized independent sample t-tests (P < 0.05), and linear regression analysis assessed the influence of preoperative cyst volume and group on bone healing.
Both groups showed similar success rates in bone formation at the 12-month follow-up, with no significant differences between them (mean (SD), control: 75.16 (19.17) vs. GBR: 82 (20.22), P > 0.05). Linear regression analysis revealed a negative correlation between preoperative cyst volume and bone regeneration in both groups (P < 0.05).
Bio-Oss may not significantly enhance bone augmentation in maxillary radicular cysts. In addition, preoperative cyst volume negatively affected the shrinkage rate of cystic lesions.
Clinicians should consider patient-specific factors such as anatomy and lesion size when determining the need for bone substitute materials. Future research could focus on optimizing treatment protocols and alternative regenerative strategies to improve patient outcomes in maxillary cyst cases.
自发性骨愈合的局限性突显了探索替代策略以增强上颌窦根囊肿病例骨再生的必要性。本回顾性研究旨在使用锥形束计算机断层扫描 (CBCT) 评估骨替代材料（即 Bio-Oss）在上颌窦根囊肿囊内切除术后对骨体积再生的影响。
将 73 例上颌窦根囊肿患者分为两组：一组接受引导骨再生 (GBR) 治疗，使用 Bio-Oss 和可吸收胶原膜（n = 35），另一组仅接受囊肿切除（n = 38）。使用 Amira 软件在 CBCT 扫描上进行容积测量，评估骨再生情况，并计算囊性病变的收缩率。使用独立样本 t 检验（P < 0.05）比较组间差异，线性回归分析评估术前囊肿体积和组对骨愈合的影响。
两组在 12 个月随访时的骨形成成功率相似，组间无显著差异（对照组：75.16 (19.17) 与 GBR：82 (20.22)，P > 0.05）。线性回归分析显示两组术前囊肿体积与骨再生呈负相关（P < 0.05）。
Bio-Oss 可能不会对上颌窦根囊肿的骨增强产生显著影响。此外，术前囊肿体积会对囊性病变的收缩率产生负面影响。
临床医生在确定是否需要使用骨替代材料时，应考虑患者的具体因素，如解剖结构和病变大小。未来的研究可以集中优化治疗方案和替代再生策略，以改善上颌囊肿病例的患者结局。
