Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, 100020, China.
BMC Cardiovasc Disord. 2022 Aug 15;22(1):372. doi: 10.1186/s12872-022-02810-7.
The atherogenic index of plasma (AIP) is a predictor for cardiovascular diseases (CVD), while hyperuricemia is an independent risk factor for a variety of CVD. Apolipoprotein AI has been found to be a protective factor for CVD. However, the role of APO AI in the association between plasma uric acid and AIP among healthy Chinese people needs to be further explored.
To evaluate the relationship between blood uric acid and AIP level in healthy Chinese people. To evaluate the relationship between blood uric acid and Apolipoprotein AI in healthy Chinese people.
A total of 3501 normal and healthy subjects who had physical examinations were divided into the hyperuricemia (HUA) group and the normouricemia (NUA) group.
The AIP of HUA group was significantly higher than that of NUA group [0.17±0.30 vs. -0.08±0.29]. Apo AI (1.33 ± 0.21 vs. 1.47 ± 0.26 g/l) and HDL-c (1.12 ± 0.27 vs. 1.36 ± 0.33 mmol/l) were significantly lower in the HUA group than in the NUA group. LDL-C (2.81 ± 0.77 vs. 2.69 ± 0.73 mmol/l), Apo B (0.96 ± 0.20 vs. 0.89 ± 0.20 g/l), FBG (5.48 ± 0.48 vs. 5.36 ± 0.48 mmol/l) and HOMA-IR [2.75 (1.92-3.91) vs. 2.18 (1.50-3.12)] was significantly higher in HAU group than the NUA group. Increases in plasma UA were associated with increases in AIP (β = 0.307, p < 0.01) and decreases in Apo AI (β = - 0.236, p < 0.01).
Hyperuricemia is an independent risk factor for high AIP level. Inhibition of Apolipoprotein AI may be one of the mechanisms of UA which is involved in the progression of cardiovascular disease.
血浆致动脉粥样硬化指数（AIP）是心血管疾病（CVD）的预测因子，而高尿酸血症是多种 CVD 的独立危险因素。载脂蛋白 AI 已被发现是 CVD 的保护因素。然而，在健康的中国人中，血浆尿酸与 AIP 之间的关系中，APO AI 的作用仍需要进一步探讨。
评估健康中国人血液尿酸与 AIP 水平之间的关系。评估健康中国人血液尿酸与载脂蛋白 AI 之间的关系。
共纳入 3501 名体检正常的健康受试者，分为高尿酸血症（HUA）组和正常尿酸血症（NUA）组。
HUA 组的 AIP 明显高于 NUA 组[0.17±0.30 vs. -0.08±0.29]。HUA 组的 Apo AI（1.33±0.21 vs. 1.47±0.26 g/L）和 HDL-c（1.12±0.27 vs. 1.36±0.33 mmol/L）明显低于 NUA 组。HUA 组 LDL-C（2.81±0.77 vs. 2.69±0.73 mmol/L）、Apo B（0.96±0.20 vs. 0.89±0.20 g/L）、FBG（5.48±0.48 vs. 5.36±0.48 mmol/L）和 HOMA-IR[2.75（1.92-3.91）vs. 2.18（1.50-3.12）]明显高于 NUA 组。血浆 UA 的升高与 AIP 的升高（β=0.307，p<0.01）和 Apo AI 的降低（β=-0.236，p<0.01）有关。
高尿酸血症是 AIP 水平升高的独立危险因素。载脂蛋白 AI 的抑制可能是 UA 参与心血管疾病进展的机制之一。
