Department of Electrical and Computer Engineering, University of Massachusetts, Amherst, MA, 01003, USA.
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Nat Commun. 2024 Mar 14;15(1):2321. doi: 10.1038/s41467-024-46636-7.
Cardiac microtissues provide a promising platform for disease modeling and developmental studies, which require the close monitoring of the multimodal excitation-contraction dynamics. However, no existing assessing tool can track these multimodal dynamics across the live tissue. We develop a tissue-like mesh bioelectronic system to track these multimodal dynamics. The mesh system has tissue-level softness and cell-level dimensions to enable stable embedment in the tissue. It is integrated with an array of graphene sensors, which uniquely converges both bioelectrical and biomechanical sensing functionalities in one device. The system achieves stable tracking of the excitation-contraction dynamics across the tissue and throughout the developmental process, offering comprehensive assessments for tissue maturation, drug effects, and disease modeling. It holds the promise to provide more accurate quantification of the functional, developmental, and pathophysiological states in cardiac tissues, creating an instrumental tool for improving tissue engineering and studies.
心脏微组织为疾病建模和发育研究提供了一个有前途的平台，这需要密切监测多模态兴奋-收缩动力学。然而，现有的评估工具无法跟踪活体组织中的这些多模态动力学。我们开发了一种类似组织的网格生物电子系统来跟踪这些多模态动力学。网格系统具有组织级的柔软度和细胞级的尺寸，可确保在组织中稳定嵌入。它与一系列石墨烯传感器集成在一起，该传感器在一个设备中独特地融合了生物电学和生物力学传感功能。该系统能够稳定地跟踪整个组织和整个发育过程中的兴奋-收缩动力学，为组织成熟、药物效应和疾病建模提供全面评估。它有望更准确地量化心脏组织的功能、发育和病理生理状态，为组织工程和研究提供一种重要工具。
