Ordzhonikidze Z V
Antibiotiki. 1979 Sep;24(9):659-63.
Efficacy of kanamycin, ampicillin and their combinations with methyluracyl and pyrogenal in experimental Coli infections was studied. The antibiotics were administered an hour after the infection. Methyluracyl and pyrogenal were used according to 2 schemes. Scheme No. I: the drug is used daily for 7 days in increasing doses, the last dose is administered 24 hours before the infection. Scheme No. 2: the drug is used once at the moment of the infection. The methyluracyl doses were: 0.5, 1.0, 2.5 mg and 5 mg and 5 mg per a mouse during the following 4 days. The pyrrogenal doses were: 5, 10, 15, 25, 30 and 35 minimum pyrogenic doses. 5 mg of methyluracyl and 35 minimum pyrogenic doses of pyrogenal were used according to scheme No. 2. The most pronounced increase in the efficacy of kanamycin, ampicillin and their combination was observed in the animals treated simultaneously with methyluracyl and pyrogenal according to scheme No. 1. The efficacy of kanamycin and ampicillin increased 3 and 2.68 times respectively. ED50 of kanamycin and ampicillin used in combination in the animals treated with methyluracyl and pyrogenal was lowered 4 and 2.9 times respectively as compared to that in the animal groups treated only with the antibiotic combination and 21 and 15.2 times respectively when the antibiotics were used alone. Sanation of the animal organs was also rather successful. A single administration of methyluracyl and pyrogenal simultaneously with the infection (scheme No. 2) had a lower effect on the efficacy.
研究了卡那霉素、氨苄青霉素及其与甲基尿嘧啶和热原质的组合在实验性大肠杆菌感染中的疗效。感染后1小时给予抗生素。甲基尿嘧啶和热原质按两种方案使用。方案一：药物每天使用7天，剂量递增，最后一剂在感染前24小时给予。方案二：在感染时一次性使用药物。甲基尿嘧啶的剂量为：每只小鼠在接下来的4天中分别为0.5毫克、1.0毫克、2.5毫克、5毫克和5毫克。热原质的剂量为：5、10、15、25、30和35个最小致热剂量。根据方案二使用5毫克甲基尿嘧啶和35个最小致热剂量的热原质。在按照方案一同时用甲基尿嘧啶和热原质治疗的动物中，观察到卡那霉素、氨苄青霉素及其组合的疗效最显著提高。卡那霉素和氨苄青霉素的疗效分别提高了3倍和2.68倍。与仅用抗生素组合治疗的动物组相比，在用甲基尿嘧啶和热原质治疗的动物中，联合使用的卡那霉素和氨苄青霉素的半数有效剂量分别降低了4倍和2.9倍，而单独使用抗生素时分别降低了21倍和15.2倍。动物器官的净化也相当成功。在感染时同时一次性给予甲基尿嘧啶和热原质（方案二）对疗效的影响较小。
