Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
J Leukoc Biol. 2024 Sep 2;116(3):469-486. doi: 10.1093/jleuko/qiae045.
Fungal infections present a significant global public health concern, impacting over 1 billion individuals worldwide and resulting in more than 3 million deaths annually. Despite considerable progress in recent years, the management of fungal infections remains challenging. The limited development of novel diagnostic and therapeutic approaches is largely attributed to our incomplete understanding of the pathogenetic mechanisms involved in these diseases. Recent research has highlighted the pivotal role of cellular metabolism in regulating the interaction between fungi and their hosts. In response to fungal infection, immune cells undergo complex metabolic adjustments to meet the energy demands necessary for an effective immune response. A comprehensive understanding of the metabolic circuits governing antifungal immunity, combined with the integration of individual host traits, holds the potential to inform novel medical interventions for fungal infections. This review explores recent insights into the immunometabolic regulation of host-fungal interactions and the infection outcome and discusses how the metabolic repurposing of immune cell function could be exploited in innovative and personalized therapeutic approaches.
真菌感染是一个重大的全球公共卫生问题，影响着全球超过 10 亿人，并导致每年超过 300 万人死亡。尽管近年来取得了相当大的进展，但真菌感染的治疗仍然具有挑战性。新型诊断和治疗方法的发展受到限制，主要是因为我们对这些疾病涉及的发病机制的了解还不完整。最近的研究强调了细胞代谢在调节真菌与其宿主之间相互作用中的关键作用。在真菌感染时，免疫细胞会发生复杂的代谢调整，以满足有效免疫反应所需的能量需求。全面了解控制抗真菌免疫的代谢通路，结合个体宿主特征的整合，有可能为真菌感染提供新的医学干预措施。这篇综述探讨了宿主-真菌相互作用和感染结果的免疫代谢调控的最新见解，并讨论了如何利用免疫细胞功能的代谢重编程来开发创新和个性化的治疗方法。
