从[植物名称]叶中分离得到的两种新的玫瑰呋喃糖苷及其抗炎活性。 （你提供的原文中“from the leaves of”后面缺少植物名称，我按格式要求翻译了完整的句子结构，实际翻译时此处需补充具体植物名称才能准确表意）
Two new megastigmane glycosides from the leaves of and their anti-inflammatory activities.
作者信息
Yang Peng-Fei, Wu Wei, Han Hang-Hang, Wang Qing-Fu, Li Lei, Wang Ze-Ning, Mao Duo-Bin, Chen Zhi-Fei
机构信息
College of Tobacco Science and Engineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Technology Center, China Tobacco Shaanxi Industrial Co., Ltd, Xian, China.
出版信息
Nat Prod Res. 2025 Jul;39(14):4050-4054. doi: 10.1080/14786419.2024.2331042. Epub 2024 Mar 19.
Two new megastigmane glycosides, (6 ,7,9)-3-oxo--ionyl-9-O--L-rhamnopyranosyl-(1''→4')--D-glucopyranoside () and (6 ,7,9)-3-oxo--ionyl-9-O--D-glucopyranosyl-(1''→6')--D-glucopyranoside (), together with six known analogues (-) were isolated from the leaves of . The structures of all metabolites were determined by comprehensive analysis of NMR and MS spectroscopic data as well as by comparison with those of previously reported. The anti-inflammatory activity of all isolates was evaluated using a lipopolysaccharide (LPS)-induced RAW264.7 cell inflammatory model, and the compounds , , , and exhibited inhibition of LPS-induced NO production in RAW264.7 macrophage cells with IC values of 42.3-61.7 μM (positive control, dexamethasone, IC = 21.3 ± 1.2 μM).
从[植物名称]的叶子中分离出两种新的巨大戟烷糖苷，即(6 ,7,9)-3-氧代-α-紫罗兰醇-9-O-α-L-鼠李吡喃糖基-(1''→4')-β-D-吡喃葡萄糖苷（）和(6 ,7,9)-3-氧代-α-紫罗兰醇-9-O-β-D-吡喃葡萄糖基-(1''→6')-β-D-吡喃葡萄糖苷（），以及六种已知类似物（-）。通过对核磁共振（NMR）和质谱（MS）光谱数据的综合分析以及与先前报道的结构进行比较，确定了所有代谢产物的结构。使用脂多糖（LPS）诱导的RAW264.7细胞炎症模型评估了所有分离物的抗炎活性，化合物、、、和在RAW264.7巨噬细胞中对LPS诱导的NO产生具有抑制作用，IC值为42.3 - 61.7μM（阳性对照，地塞米松，IC = 21.3 ± 1.2μM）。
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